New macrolactone of the desertomycin family from Streptomyces spectabilis.

The non-polyenic macrocyclic antibiotic complex 1012 was isolated from the culture broth of a strain Streptomyces spectabilis 1. The complex was found to belong to the desertomycin complex. Three main compounds of complex 1012 were separated and purified by preparative chromatographic methods. The identification was performed by UV, IR, NMR and mass-spectrometric studies. It was proved that two of the compounds with MW. 1191, C61H109NO21 and MW. 1190, C61H106O22 were identical to desertomycin A and D. The other com-pound with MW.1028, C55H96O17 is new macrolactone, named deser-tomycin E. The structures were established by detailed spectroscopic analysis.