Literature DB >> 9087860

Cloning and functional expression of the rat brain KIR6.2 channel.

M Takano1, T Ishii, L H Xie.   

Abstract

We obtained cDNA encoding KIR6.2 channel from the rat brain cDNA library. The reconstituted K+ channel with KIR6.2 and SUR1 genes retained properties similar to those reported in the native ATP-sensitive K+ channel including run-down and recovery of channel activity. When KIR6.2 was co-expressed with CFTR or MDR1, no K+ channel activity was recorded.

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Year:  1996        PMID： 9087860     DOI： 10.2170/jjphysiol.46.491

Source DB:  PubMed          Journal:  Jpn J Physiol        ISSN： 0021-521X


  4 in total

1.  Myocardial ischemia induces differential regulation of KATP channel gene expression in rat hearts.

Authors:  M Akao; H Otani; M Horie; M Takano; A Kuniyasu; H Nakayama; I Kouchi; T Murakami; S Sasayama
Journal:  J Clin Invest       Date:  1997-12-15       Impact factor: 14.808

2.  Molecular determinants of KATP channel inhibition by ATP.

Authors:  S J Tucker; F M Gribble; P Proks; S Trapp; T J Ryder; T Haug; F Reimann; F M Ashcroft
Journal:  EMBO J       Date:  1998-06-15       Impact factor: 11.598

3.  Wortmannin, an inhibitor of phosphatidylinositol kinases, blocks the MgATP-dependent recovery of Kir6.2/SUR2A channels.

Authors:  L H Xie; M Takano; M Kakei; M Okamura; A Noma
Journal:  J Physiol       Date:  1999-02-01       Impact factor: 5.182

4.  Cytoplasmic terminus domains of Kir6.x confer different nucleotide-dependent gating on the ATP-sensitive K+ channel.

Authors:  M Takano; L H Xie; H Otani; M Horie
Journal:  J Physiol       Date:  1998-10-15       Impact factor: 5.182
  4 in total

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