| Literature DB >> 9085970 |
Z Fang1, D Gong, P Ionescu, M J Laster, E I Eger, J Kendig.
Abstract
The potency of conventional inhaled anesthetics increases with increasing age: the 50% effective dose (minimum alveolar anesthetic concentration [MAC]) for anesthesia in the neonatal animal or human exceeds MAC in the young adult by approximately 30% to 60%. We tested whether this relationship also applies to the alkanols, using ethanol as a representative alkanol. We found that the MAC of ethanol in neonatal rats was 1.86 times (86% greater than) the MAC for adult rats, based on ethanol partial pressures determined from brain specimens. In contrast, the MAC of desflurane in neonatal rats was 1.19 times (19% greater than) the MAC for adult rats, less than one-fourth the 86% found for ethanol. These differences must be explained by any unitary theory of narcosis. Alternatively, the mechanistic basis for alkanol versus conventional inhaled anesthetics may differ in part or whole.Entities:
Mesh：
Substances：
Year: 1997 PMID： 9085970 DOI： 10.1097/00000539-199704000-00028
Source DB: PubMed Journal: Anesth Analg ISSN： 0003-2999 Impact factor: 5.108