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Literature DB >> 9085845

A novel protein shared by RNase MRP and RNase P.

Abstract

We have isolated suppressors of the temperature-sensitive rRNA processing mutation rrp2-2 in Saccharomyces cerevisiae. A class of extragenic suppressors was mapped to the YBR257w reading frame in the right arm of Chromosome II. Characterization of this gene, renamed POP4, shows that the gene product is necessary both for normal 5.8S rRNA processing and for processing of tRNA. Immunoprecipitation studies indicate that Pop4p is associated with both RNase MRP and RNase P. The protein is also required for accumulation of RNA from each of the two ribonucleoprotein particles.

Entities: Gene Species

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Year: 1997 PMID： 9085845 PMCID： PMC1369490

Source DB: PubMed Journal: RNA ISSN： 1355-8382 Impact factor: 4.942

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Cited

43 in total

A novel protein shared by RNase MRP and RNase P.

Review 1. Protein trans-acting factors involved in ribosome biogenesis in Saccharomyces cerevisiae.

2. Degradation of ribosomal RNA precursors by the exosome.

Review 3. Eukaryotic ribonuclease P: increased complexity to cope with the nuclear pre-tRNA pathway.

4. RNA-protein interactions in the human RNase MRP ribonucleoprotein complex.

5. Nop58p is a common component of the box C+D snoRNPs that is required for snoRNA stability.

6. Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P.

Review 7. Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes.

8. An active precursor in assembly of yeast nuclear ribonuclease P.

9. Functional equivalence of hairpins in the RNA subunits of RNase MRP and RNase P in Saccharomyces cerevisiae.

10. Nucleolar localization of early tRNA processing.