Literature DB >> 9085495

Presynaptic inhibition by serotonin: a possible mechanism for switching motor output of the hypoglossal nucleus.

J H Singer1, A J Berger.   

Abstract

We examined the influence of serotonin (5-HT), an important state-dependent neuromodulator, on synaptic transmission to hypoglossal motoneurons (HMs). Our data demonstrate that 5-HT acts presynaptically to inhibit excitatory (glutamatergic) synaptic currents recorded in HMs. We discuss this result in relation to the role of 5-HT in state-dependent modulation of respiration-related activity in HMs.

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Year:  1996        PMID： 9085495     DOI： 10.1093/sleep/19.suppl_10.146

Source DB:  PubMed          Journal:  Sleep        ISSN： 0161-8105            Impact factor:   5.849


  9 in total

1.  Membrane receptors involved in modulation of responses of spinal dorsal horn interneurons evoked by feline group II muscle afferents.

Authors:  Kimberly J Dougherty; B Anne Bannatyne; Elzbieta Jankowska; Piotr Krutki; David J Maxwell
Journal:  J Neurosci       Date:  2005-01-19       Impact factor: 6.167

2.  Differential respiratory control of the upper airway and diaphragm muscles induced by 5-HT1A receptor ligands.

Authors:  Stephane Besnard; Hanan Khemiri; Fabienne Masse; Pierre Denise; Marion Verdaguer; Christian Gestreau
Journal:  Sleep Breath       Date:  2011-01-09       Impact factor: 2.816

3.  Calcium influx-independent depression of transmitter release by 5-HT at lamprey spinal cord synapses.

Authors:  M Takahashi; R Freed; T Blackmer; S Alford
Journal:  J Physiol       Date:  2001-04-15       Impact factor: 5.182

4.  Microdialysis perfusion of 5-HT into hypoglossal motor nucleus differentially modulates genioglossus activity across natural sleep-wake states in rats.

Authors:  A Jelev; S Sood; H Liu; P Nolan; R L Horner
Journal:  J Physiol       Date:  2001-04-15       Impact factor: 5.182

Review 5.  Synaptic control of motoneuronal excitability.

Authors:  J C Rekling; G D Funk; D A Bayliss; X W Dong; J L Feldman
Journal:  Physiol Rev       Date:  2000-04       Impact factor: 37.312

6.  Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei.

Authors:  C Töpert; F Döring; E Wischmeyer; C Karschin; J Brockhaus; K Ballanyi; C Derst; A Karschin
Journal:  J Neurosci       Date:  1998-06-01       Impact factor: 6.167

7.  Ventilation and neurochemical changes during µ-opioid receptor activation or blockade of excitatory receptors in the hypoglossal motor nucleus of goats.

Authors:  Thomas M Langer; Suzanne E Neumueller; Emma Crumley; Nicholas J Burgraff; Sawan Talwar; Matthew R Hodges; Lawrence Pan; Hubert V Forster
Journal:  J Appl Physiol (1985)       Date:  2017-08-24

Review 8.  Pathophysiology of sleep apnea.

Authors:  Jerome A Dempsey; Sigrid C Veasey; Barbara J Morgan; Christopher P O'Donnell
Journal:  Physiol Rev       Date:  2010-01       Impact factor: 37.312

Review 9.  The neuropharmacology of upper airway motor control in the awake and asleep states: implications for obstructive sleep apnoea.

Authors:  R L Horner
Journal:  Respir Res       Date:  2001-08-10
  9 in total

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