OBJECTIVE: This study addressed the efficacy of singularly applied topical doxymycine in the pain relief treatment of recurrent aphthous stomatitis. STUDY DESIGN:Thirty-one patients with recurrent aphthous lesions were examined and divided randomly in two groups. Experimental group (n = 15) received a topical application of doxymycine and controls (n = 16) received calcii gluconase in the same manner. Medications were covered by isobutyl cyanoacrylate (Iso-Dent). Application was made only once during the recurrent aphthous ulcer episode. RESULTS: Patients recorded their pain level on a visual analog scale for 10 days during healing. Pain decreased more rapidly in the experimental group, and a statistically significant difference (p < 0.05) in the pain intensity was found from the second to the seventh day after application of doxymycine. CONCLUSIONS: In recurrent aphthous ulcers, singular treatment of topical doxymycine-cyanoacrylate relieves the pain intensity remarkably for 6 days after a 1 day latency period. Topical doxymycine treatment further exerts potential to directly prevent tissue destruction and to indirectly suppress host inflammatory reaction.
RCT Entities:
OBJECTIVE: This study addressed the efficacy of singularly applied topical doxymycine in the pain relief treatment of recurrent aphthous stomatitis. STUDY DESIGN: Thirty-one patients with recurrent aphthous lesions were examined and divided randomly in two groups. Experimental group (n = 15) received a topical application of doxymycine and controls (n = 16) received calcii gluconase in the same manner. Medications were covered by isobutyl cyanoacrylate (Iso-Dent). Application was made only once during the recurrent aphthous ulcer episode. RESULTS:Patients recorded their pain level on a visual analog scale for 10 days during healing. Pain decreased more rapidly in the experimental group, and a statistically significant difference (p < 0.05) in the pain intensity was found from the second to the seventh day after application of doxymycine. CONCLUSIONS: In recurrent aphthous ulcers, singular treatment of topical doxymycine-cyanoacrylate relieves the pain intensity remarkably for 6 days after a 1 day latency period. Topical doxymycine treatment further exerts potential to directly prevent tissue destruction and to indirectly suppress host inflammatory reaction.
Authors: Vicky E Jones; Kristi J McIntyre; Devchand Paul; Sharon T Wilks; Sharon M Ondreyco; Scot Sedlacek; Anton Melnyk; Sanjay P Oommen; Yunfei Wang; Susan R Peck; Joyce A O'Shaughnessy Journal: Oncologist Date: 2019-03-04
Authors: Sadeq Ali Al-Maweri; Esam Halboub; Sajna Ashraf; Ahmed Y Alqutaibi; Nashwan Mohammed Qaid; Kamila Yahya; Mohammed Nasser Alhajj Journal: BMC Oral Health Date: 2020-08-24 Impact factor: 2.757