Robertsonian fusion leading to the formation of stable dicentric chromosome in an ascites cell line of the mouse.

The dicentric nature of a marker metacentric chromosome originated by robertsonian fusion has been established in the ascites cells of mouse sarcoma 180. C-banding analysis has revealed that the metacentric is actually a dicentric with 2 closely situated C-positive heterochromatic zones. The nature of the centromeres and the NF value of the cell indicate that this meta-dicentric marker has originated by breakage and fusion within each of the short arms of 2 acrocentric chromosomes.