Literature DB >> 9083470

Design of highly potent noncovalent thrombin inhibitors that utilize a novel lipophilic binding pocket in the thrombin active site.

T J Tucker1, W C Lumma, A M Mulichak, Z Chen, A M Naylor-Olsen, S D Lewis, R Lucas, R M Freidinger, L C Kuo.   

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Year:  1997        PMID： 9083470     DOI： 10.1021/jm960762y

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  2 in total

1.  Quantum and molecular dynamics study for binding of macrocyclic inhibitors to human alpha-thrombin.

Authors:  Emilia L Wu; Ye Mei; KeLi Han; John Z H Zhang
Journal:  Biophys J       Date:  2007-03-23       Impact factor: 4.033

2.  Thrombin inhibitors with novel P1 binding pocket functionality: free energy of binding analysis.

Authors:  Gregor Mlinsek; Marko Oblak; Milan Hodoscek; Tom Solmajer
Journal:  J Mol Model       Date:  2006-09-30       Impact factor: 1.810
  2 in total

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