Literature DB >> 9081298

Plants as bioreactors for biopharmaceuticals: regulatory considerations.

L Miele1.   

Abstract

Plants are one of several novel hosts that can be used for the production of recombinant biopharmaceuticals such as cytokines, hormones, monoclonal antibodies, enzymes and vaccines. The novelty of this technology and its wide range of potential applications require an assessment of possible regulatory concerns in the clinical development of plant-derived biopharmaceuticals. General principles extrapolated from experience gained with biotechnology products from other sources can serve as a foundation to develop scientifically sound strategies for the large-scale production and clinical development of safe and effective biopharmaceuticals in plant hosts.

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Year:  1997        PMID： 9081298     DOI： 10.1016/S0167-7799(97)84202-3

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN： 0167-7799            Impact factor:   19.536


  11 in total

1.  Gene regulation in planta by plant-derived engineered zinc finger protein transcription factors.

Authors:  Rachel Holmes-Davis; Guofu Li; Andrew C Jamieson; Edward J Rebar; Qiang Liu; Yanhong Kong; Casey C Case; Philip D Gregory
Journal:  Plant Mol Biol       Date:  2005-02       Impact factor: 4.076

2.  Expression of active hBMP2 in transgenic tobacco plants.

Authors:  Guangli Suo; Bing Chen; Jingyu Zhang; Yuan Gao; Xia Wang; Zhengquan He; Jianwu Dai
Journal:  Plant Cell Rep       Date:  2006-07-04       Impact factor: 4.570

Review 3.  Microalgae as bioreactors.

Authors:  Tara L Walker; Saul Purton; Douglas K Becker; Chris Collet
Journal:  Plant Cell Rep       Date:  2005-08-31       Impact factor: 4.570

4.  Galactose-extended glycans of antibodies produced by transgenic plants.

Authors:  H Bakker; M Bardor; J W Molthoff; V Gomord; I Elbers; L H Stevens; W Jordi; A Lommen; L Faye; P Lerouge; D Bosch
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-27       Impact factor: 11.205

5.  Influence of growth conditions and developmental stage on N-glycan heterogeneity of transgenic immunoglobulin G and endogenous proteins in tobacco leaves.

Authors:  I J Elbers; G M Stoopen; H Bakker; L H Stevens; M Bardor; J W Molthoff; W J Jordi; D Bosch; A Lommen
Journal:  Plant Physiol       Date:  2001-07       Impact factor: 8.340

6.  Transient Expression of cor Gene in Papaver somniferum.

Authors:  Bahman Hosseini; Farajollah Shahriari-Ahmadi; Haleh Hashemi; Mohammad-Hasan Marashi; Mahdi Mohseniazar; Alireza Farokhzad; Masoume Sabokbari
Journal:  Bioimpacts       Date:  2011-12-26

7.  Analysis of the limitations of hepatitis B surface antigen expression in soybean cell suspension cultures.

Authors:  T R Ganapathi; G B Sunil Kumar; L Srinivas; C J Revathi; V A Bapat
Journal:  Plant Cell Rep       Date:  2007-05-30       Impact factor: 4.570

8.  Production of recombinant single chain antibodies (scFv) in vegetatively reproductive Kalanchoe pinnata by in planta transformation.

Authors:  Yuchul Jung; Yong Rhee; Chung-Kyoon Auh; Hyekyung Shim; Jung-Jin Choi; Suk-Tae Kwon; Joo-Sung Yang; Donggiun Kim; Myung-Hee Kwon; Yong-Sung Kim; Sukchan Lee
Journal:  Plant Cell Rep       Date:  2009-08-18       Impact factor: 4.570

9.  Bipartite and tripartite Cucumber mosaic virus-based vectors for producing the Acidothermus cellulolyticus endo-1,4-β-glucanase and other proteins in non-transgenic plants.

Authors:  Min Sook Hwang; Benjamin E Lindenmuth; Karen A McDonald; Bryce W Falk
Journal:  BMC Biotechnol       Date:  2012-09-21       Impact factor: 2.563

Review 10.  Molecular farming of pharmaceutical proteins.

Authors:  R Fischer; N Emans
Journal:  Transgenic Res       Date:  2000       Impact factor: 3.145
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