Literature DB >> 9080421

Injections of nociceptin into nucleus accumbens shell or ventromedial hypothalamic nucleus increase food intake.

T R Stratford1, M R Holahan, A E Kelley.   

Abstract

The novel opioid receptor ORL1 is widely distributed throughout the CNS of the rat, and is present in high densities in several brain regions known to participate in the control of food intake. We injected a recently identified endogenous agonist of this receptor, nociceptin, into two of these feeding-related areas. Microinjections of nociceptin (2.5-25 nmol) into either the ventromedial hypothalamic nucleus or the nucleus accumbens shell significantly increased food intake in rats. We believe this to be the first report of a specific effect of nociceptin on a motivated behavior.

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Year:  1997        PMID： 9080421     DOI： 10.1097/00001756-199701200-00009

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  24 in total

Review 1.  Orphan anxiety.

Authors:  J R Walker; G F Koob
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-23       Impact factor: 11.205

2.  Parsing the hedonic and motivational influences of nociceptin on feeding using licking microstructure analysis in mice.

Authors:  Ian A Mendez; Nigel T Maidment; Niall P Murphy
Journal:  Behav Pharmacol       Date:  2016-09       Impact factor: 2.293

Review 3.  Pharmacology of nociceptin and its receptor: a novel therapeutic target.

Authors:  G Calo'; R Guerrini; A Rizzi; S Salvadori; D Regoli
Journal:  Br J Pharmacol       Date:  2000-04       Impact factor: 8.739

4.  Central nociceptin/orphanin FQ system elevates food consumption by both increasing energy intake and reducing aversive responsiveness.

Authors:  Pawel K Olszewski; Martha K Grace; Shahrzad Shirazi Fard; Madeleine Le Grevès; Anica Klockars; Maurizio Massi; Helgi B Schiöth; Allen S Levine
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2010-04-28       Impact factor: 3.619

5.  Orphanin FQ/nociceptin attenuates motor stimulation and changes in nucleus accumbens extracellular dopamine induced by cocaine in rats.

Authors:  K Lutfy; T Do; N T Maidment
Journal:  Psychopharmacology (Berl)       Date:  2001-02       Impact factor: 4.530

6.  Caloric restriction increases the sensitivity to the hyperphagic effect of nociceptin/orphanin FQ limiting its ability to reduce binge eating in female rats.

Authors:  Maria Vittoria Micioni Di Bonaventura; Massimo Ubaldi; Sonia Liberati; Roberto Ciccocioppo; Maurizio Massi; Carlo Cifani
Journal:  Psychopharmacology (Berl)       Date:  2013-03-02       Impact factor: 4.530

7.  The effect of serotonergic system on nociceptin/orphanin FQ induced food intake in chicken.

Authors:  Morteza Zendehdel; Kasra Mokhtarpouriani; Vahab Babapour; Ali Baghbanzadeh; Maryam Pourrahimi; Shahin Hassanpour
Journal:  J Physiol Sci       Date:  2013-04-25       Impact factor: 2.781

8.  Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors.

Authors:  Alexander Kuzmin; Johan Sandin; Lars Terenius; Sven Ove Ogren
Journal:  Br J Pharmacol       Date:  2003-12-08       Impact factor: 8.739

9.  The bed nucleus is a neuroanatomical substrate for the anorectic effect of corticotropin-releasing factor and for its reversal by nociceptin/orphanin FQ.

Authors:  Roberto Ciccocioppo; Amalia Fedeli; Daina Economidou; Federica Policani; Friedbert Weiss; Maurizio Massi
Journal:  J Neurosci       Date:  2003-10-15       Impact factor: 6.167

10.  Nutritional state influences Nociceptin/Orphanin FQ peptide receptor expression in the dorsal raphe nucleus.

Authors:  Magdalena J Przydzial; Alastair S Garfield; Daniel D Lam; Stephen P Moore; Mark L Evans; Lora K Heisler
Journal:  Behav Brain Res       Date:  2009-09-16       Impact factor: 3.332
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