| Literature DB >> 908029 |
R L Levy, M H Barrington, R A Lerner, G F Griffin, C E Whitmire.
Abstract
The immunosuppressive effects of 3-methylcholanthrene (MCA) given intratracheally have been shown to correlate with susceptibility of some inbred strains of mice to MCA-induced carcinogenesis. In susceptible strains of mice, C3Hf and C57BL/6, intratracheal administration of MCA resulted in profound systemic immunodepression. This effect was not observed in resistant DBA/2 mice. This immunodepressive effect correlated with the inducibility of the aryl hydrocarbon hydroxylase enzyme complex and the inducibility of pulmonary tumors by MCA.Entities:
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Year: 1977 PMID： 908029
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701