| Literature DB >> 9079284 |
A Fang1, D L Pierson, S K Mishra, D W Koenig, A L Demain.
Abstract
Rotating bioreactors designed at NASA's Johnson Space Center were used to simulate a microgravity environment in which to study secondary metabolism. The system examined was beta-lactam antibiotic production by Streptomyces clavuligerus. Both growth and beta-lactam production occurred in simulated microgravity. Stimulatory effects of phosphate and L-lysine, previously detected in normal gravity, also occurred in simulated microgravity. The degree of beta-lactam antibiotic production was markedly inhibited by simulated microgravity.Entities:
Keywords: NASA Center JSC; NASA Discipline Environmental Health; NASA Discipline Number 04-10; NASA Program Environmental Health
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Year: 1997 PMID： 9079284 DOI： 10.1038/sj.jim.2900345
Source DB: PubMed Journal: J Ind Microbiol Biotechnol ISSN： 1367-5435 Impact factor: 3.346