Literature DB >> 9078685

Clinical significance of IgG Fc receptors and Fc gamma R-directed immunotherapies.

Y M Deo1, R F Graziano, R Repp, J G van de Winkel.   

Abstract

Fc receptors for IgG (Fc gamma Rs) can trigger the inflammatory, cytotoxic and hypersensitivity functions of immune effector cells. Activation or deactivation of effector cells via Fc gamma Rs can be exploited to develop novel therapies for cancer, infectious diseases and autoimmune disorders. Initial results of clinical trials for several Fc gamma R-directed immunotherapies show the potential promise of this approach.

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Year:  1997        PMID： 9078685     DOI： 10.1016/s0167-5699(97)01007-4

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  41 in total

Review 1.  Functions of the Fc receptors for immunoglobulin G.

Authors:  B K Flesch; J Neppert
Journal:  J Clin Lab Anal       Date:  2000       Impact factor: 2.352

2.  Increased distribution and expression of CD64 on blood polymorphonuclear cells from patients with the systemic inflammatory response syndrome (SIRS).

Authors:  S S Qureshi; S M Lewis; V A Gant; D Treacher; B H Davis; K A Brown
Journal:  Clin Exp Immunol       Date:  2001-08       Impact factor: 4.330

3.  Correlation of ADCC activity with cytokine release induced by the stably expressed, glyco-engineered humanized Lewis Y-specific monoclonal antibody MB314.

Authors:  Ralf Kircheis; Nicole Halanek; Iris Koller; Wolfgang Jost; Manfred Schuster; Gilbert Gorr; Klaus Hajszan; Andreas Nechansky
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4.  Role of apoptotic signaling pathways in regulation of inflammatory responses to ricin in primary murine macrophages.

Authors:  Veselina Korcheva; John Wong; Meghan Lindauer; David B Jacoby; Mihail S Iordanov; Bruce Magun
Journal:  Mol Immunol       Date:  2007-01-25       Impact factor: 4.407

5.  Efficient inhibition of HIV-1 replication in human immature monocyte-derived dendritic cells by purified anti-HIV-1 IgG without induction of maturation.

Authors:  Vincent Holl; Maryse Peressin; Sylvie Schmidt; Thomas Decoville; Susan Zolla-Pazner; Anne-Marie Aubertin; Christiane Moog
Journal:  Blood       Date:  2006-02-09       Impact factor: 22.113

6.  A versatile bifunctional dendritic cell targeting vaccine vector.

Authors:  Welson W Wang; Dipankar Das; Mavanur R Suresh
Journal:  Mol Pharm       Date:  2009 Jan-Feb       Impact factor: 4.939

7.  The involvement of Fc gamma receptor gene polymorphisms in Kawasaki disease.

Authors:  M Biezeveld; J Geissler; M Merkus; I M Kuipers; J Ottenkamp; T Kuijpers
Journal:  Clin Exp Immunol       Date:  2007-01       Impact factor: 4.330

8.  FcgammaRIa-gamma-chain complexes trigger antibody-dependent cell-mediated cytotoxicity (ADCC) in CD5+ B cell/macrophage IIA1.6 cells.

Authors:  M J Van Vugt; I E Van den Herik-Oudijk; J G Van de Winkel
Journal:  Clin Exp Immunol       Date:  1998-09       Impact factor: 4.330

9.  Human intravenous immunoglobulin (IVIG) preparations degranulate human neutrophils in vitro.

Authors:  J L Teeling; E R De Groot; A J Eerenberg; W K Bleeker; G Van Mierlo; L A Aarden; C E Hack
Journal:  Clin Exp Immunol       Date:  1998-11       Impact factor: 4.330

10.  Complement component C7 deficiency in a Spanish family.

Authors:  M F Vázquez-Bermúdez; S Barroso; K Walter; A J Alvarez; A Alarcón; M López-Trascasa; I Wichmann; F Aguilar; A Núñez-Roldán; B Sánchez
Journal:  Clin Exp Immunol       Date:  2003-08       Impact factor: 4.330
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