| Literature DB >> 9078363 |
Abstract
The human Aniridia, the murine Small eye, and the eyeless mutations of Drosophila affect homologous (Pax-6) genes that contain both a paired- and a homeobox. By ectopic expression of these genes, functional eyes can be induced on the legs, wings, and antennae of the fly, indicating that eyeless (Pax-6) is the master control gene for eye morphogenesis. The finding of Pax-6 from flatworms to humans suggests that eyeless is a universal master control gene and that the various types of eyes in the various animal phyla may have evolved from a single prototype.Entities:
Mesh：
Substances：
Year: 1996 PMID： 9078363 DOI： 10.1046/j.1365-2443.1996.11011.x
Source DB: PubMed Journal: Genes Cells ISSN： 1356-9597 Impact factor: 1.891