Case report: neurochemical, physiological, and behavioral effects of bright light therapy on a cortically blind patient.

The present study evaluated the effects of bright light therapy on a patient with cortical blindness. Behavioral indices of functioning included the appraisal of mood, fatigue, appetite and orientation. Physiological measures assessed were blood pressure and temperature. Blood serum samples were analyzed for 5-HIAA and norepinephrine (NE). For the control and follow-up, the patient was exposed to 30 minutes of red light (300-lux), and thirty minutes of white light (10,000-lux) was used for treatment. High-pressure liquid chromatography analyses of blood serum samples revealed no change in serotonin (5-HT). However, an increase in blood NE was indicated following light treatment (red light: 12.7 ng/ml, white light: 43.5 ng/ml and, red light: 27.5 ng/ml). Analysis of data revealed significant differences in baseline and treatment scores for 4 of the outcome measures.