OBJECTIVE: To measure and compare scanning laser polarimeter measurements of the nerve fiber layer in normal subjects and in patients with ocular hypertension (OHT). METHODS:Scanning laser polarimetry was performed in 39 normal subjects and 39 age-matched patients with OHT. One eye of each patient was randomly selected for the study. For each eye, a mean retardation map was calculated from 3 separate scans of 65536 individual retinal locations (256 x 256 pixels). Retardation measurements within a 10-pixel-wide band located concentrically with the disc margin at 1.7-disc diameters were evaluated. RESULTS:Mean (+/-SD) retardation (in degrees) was significantly higher (P = .03) in normal subjects (10.4 +/- 1.5 degrees) than in patients with OHT (9.7 +/- 1.0 degrees). In the inferior retina, mean +/-SD retardation was higher (P = .03) in normal subjects (10.8 +/- 1.7 degrees) than in patients with OHT (10.1 +/- 1.0 degrees). In the superior retina, mean +/-SD retardation also was higher in normal subjects (9.8 +/- 1.6 degrees) than in patients with OHT (9.3 +/- 1.2 degrees), although the difference was not statistically significant (P = .19). Retardation measurements for 3 of eight 45 degrees sectors around the disc were significantly higher in normal subjects than in patients with OHT. CONCLUSION:Retardation measurements with the scanning laser polarimeter were significantly lower in patients with OHT than in normal subjects.
RCT Entities:
OBJECTIVE: To measure and compare scanning laser polarimeter measurements of the nerve fiber layer in normal subjects and in patients with ocular hypertension (OHT). METHODS: Scanning laser polarimetry was performed in 39 normal subjects and 39 age-matched patients with OHT. One eye of each patient was randomly selected for the study. For each eye, a mean retardation map was calculated from 3 separate scans of 65536 individual retinal locations (256 x 256 pixels). Retardation measurements within a 10-pixel-wide band located concentrically with the disc margin at 1.7-disc diameters were evaluated. RESULTS: Mean (+/-SD) retardation (in degrees) was significantly higher (P = .03) in normal subjects (10.4 +/- 1.5 degrees) than in patients with OHT (9.7 +/- 1.0 degrees). In the inferior retina, mean +/-SD retardation was higher (P = .03) in normal subjects (10.8 +/- 1.7 degrees) than in patients with OHT (10.1 +/- 1.0 degrees). In the superior retina, mean +/-SD retardation also was higher in normal subjects (9.8 +/- 1.6 degrees) than in patients with OHT (9.3 +/- 1.2 degrees), although the difference was not statistically significant (P = .19). Retardation measurements for 3 of eight 45 degrees sectors around the disc were significantly higher in normal subjects than in patients with OHT. CONCLUSION:Retardation measurements with the scanning laser polarimeter were significantly lower in patients with OHT than in normal subjects.
Authors: R Lauande-Pimentel; R A Carvalho; H C Oliveira; D C Gonçalves; L M Silva; V P Costa Journal: Br J Ophthalmol Date: 2001-05 Impact factor: 4.638
Authors: Robert Laemmer; Folkert K Horn; Arne Viestenz; Anselm G Juenemann; Christian Y Mardin Journal: Graefes Arch Clin Exp Ophthalmol Date: 2005-09-21 Impact factor: 3.117