| Literature DB >> 9075786 |
S H Lang1, C M West, L Jones, B Brooks, C Kasper, E deWynter, N G Testa.
Abstract
A study was made of the in vitro effects of recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on breast, prostate, cervix and colon cancers. Tumour growth was assessed using a soft agar clonogenic assay. Stimulation of megakaryocyte numbers was seen in liquid culture following 10 ng/ml PEG-rHuMGDF. The same concentration led to no significant difference in colony-forming efficiencies for 22 of 25 tumour samples. A significant reduction in colony-forming efficiencies was seen for the remaining 3 specimens. These results suggest that PEG-rHuMGDF will not stimulate tumour growth in vivo.Entities:
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Year: 1997 PMID： 9075786 DOI： 10.1159/000227678
Source DB: PubMed Journal: Oncology ISSN： 0030-2414 Impact factor: 2.935