Literature DB >> 9075215

Streptococcus pneumoniae produces a second haemolysin that is distinct from pneumolysin.

J R Canvin1, J C Paton, G J Boulnois, P W Andrew, T J Mitchell.   

Abstract

Pneumococci are described as alpha-haemolytic but under certain circumstances they produce zones of beta-haemolysis on blood-containing medium. This observation was investigated using wild type strains and a genetically-modified strain unable to produce the haemolytic toxin, pneumolysin. beta-haemolysis was produced by all pneumococci tested. It was not inhibited by anti-pneumolysin antibody but could be inactivated by cholesterol. These data confirm that pneumococci elaborate a second haemolysin, distinct from pneumolysin.

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Year:  1997        PMID： 9075215     DOI： 10.1006/mpat.1996.0098

Source DB:  PubMed          Journal:  Microb Pathog        ISSN： 0882-4010            Impact factor:   3.738


  7 in total

1.  Microarray-based identification of a novel Streptococcus pneumoniae regulon controlled by an autoinduced peptide.

Authors:  A de Saizieu; C Gardès; N Flint; C Wagner; M Kamber; T J Mitchell; W Keck; K E Amrein; R Lange
Journal:  J Bacteriol       Date:  2000-09       Impact factor: 3.490

Review 2.  Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope.

Authors:  W W Navarre; O Schneewind
Journal:  Microbiol Mol Biol Rev       Date:  1999-03       Impact factor: 11.056

3.  Large-scale identification of virulence genes from Streptococcus pneumoniae.

Authors:  A Polissi; A Pontiggia; G Feger; M Altieri; H Mottl; L Ferrari; D Simon
Journal:  Infect Immun       Date:  1998-12       Impact factor: 3.441

4.  The role of cholesterol in the activity of pneumolysin, a bacterial protein toxin.

Authors:  Marcelo Nöllmann; Robert Gilbert; Timothy Mitchell; Michele Sferrazza; Olwyn Byron
Journal:  Biophys J       Date:  2004-05       Impact factor: 4.033

5.  Cholesterol as treatment for pneumococcal keratitis: cholesterol-specific inhibition of pneumolysin in the cornea.

Authors:  Mary E Marquart; Kathryn S Monds; Clare C McCormick; Sherrina N Dixon; Melissa E Sanders; Julian M Reed; Larry S McDaniel; Armando R Caballero; Richard J O'Callaghan
Journal:  Invest Ophthalmol Vis Sci       Date:  2007-06       Impact factor: 4.799

6.  Eukaryotic-type serine/threonine protein kinase StkP is a global regulator of gene expression in Streptococcus pneumoniae.

Authors:  Lenka Sasková; Linda Nováková; Marek Basler; Pavel Branny
Journal:  J Bacteriol       Date:  2007-04-06       Impact factor: 3.490

7.  A comparison of pneumolysin activity and concentration in vitro and in vivo in a rabbit endophthalmitis model.

Authors:  Melissa E Sanders; Erin W Norcross; Quincy C Moore; Chinwendu Onwubiko; Lauren B King; Jonathan Fratkin; Mary E Marquart
Journal:  Clin Ophthalmol       Date:  2008-12
  7 in total

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