Literature DB >> 907363

New experimental model for the primary evaluation of topical contra-inflammatory agents.

E G Weirich, J K Longauer, A H Kirkwood.   

Abstract

Assays of steroidal and non-steroidal drugs in an experimental model of dermatitis induced in the ear of the rabbit by the application of a solution of croton oil revealed clearly differentiable inhibitory effects on the rise in skin temperature, the oedema and the increase in tissue mass due to the inflammatory process. The results obtained in this test system fairly accurately reflect the relative therapeutic potencies of known dermatocorticoids and, in conjunction with those found by other methods, afford a more exact characterization of the activity profiles of non-steroidal contra-inflammatory agents.

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Year:  1977        PMID： 907363     DOI： 10.1007/bf00557954

Source DB:  PubMed          Journal:  Arch Dermatol Res            Impact factor:   3.017


  33 in total

1.  [Antiphlogistic effect of pyrazols, especially of irgapyrin, in peroral and parenteral administration].

Authors:  G WILHELMI
Journal:  Schweiz Med Wochenschr       Date:  1950-09-02

2.  Dermatopharmacology of salicylic acid. III. Topical contra-inflammatory effect of salicylic acid and other drugs in animal experiments.

Authors:  E G Weirich; J K Longauer; A H Kirkwood
Journal:  Dermatologica       Date:  1976

3.  [Stearadenotrophic effect of androgens in rabbit ear skin. Histometric studies of the activity of the sebaceous glands. First communication (author's transl)].

Authors:  E G Weirich; J Longauer
Journal:  Dermatologica       Date:  1974

4.  Local anti-inflammatory properties of etoclofene. A new fenamate derivative.

Authors:  G B Fregnan; A L Torsello; S Brunet
Journal:  Pharmacology       Date:  1974       Impact factor: 2.547

5.  [Skin vasoconstriction assay in the evaluation of topical corticosteroids in man. General problems and results obtained in a series of tests (author's transl)].

Authors:  E G Weirich; U Lutz
Journal:  Dermatologica       Date:  1973

6.  [Evaluation of topical corticosteroid activity by skin inflammatory tests].

Authors:  R Tagliavini; A Colombi
Journal:  Boll Chim Farm       Date:  1972-02

7.  [Contact-allergic eczematous test reaction as test model of the anti-eczematous effect of locally used corticosteroids].

Authors:  M Go
Journal:  Arzneimittelforschung       Date:  1969-11

8.  Anti-inflammatory action of a benzyl glucofuranoside applied topically.

Authors:  L Riesterer; R Jaques
Journal:  Experientia       Date:  1968-06-15

9.  [Reflexphotometric determinations of vasoconstriction after topical application of steroids. IV. Time slope of vasoconstriction and reactive vasodilatation (author's transl)].

Authors:  P Altmeyer; H Zaun
Journal:  Arch Dermatol Res       Date:  1976-03-10       Impact factor: 3.017

10.  [Practical importance and the criteria of value of external corticoids].

Authors:  E G Weirich
Journal:  Wien Med Wochenschr       Date:  1966-08-06
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  3 in total

1.  Anti-inflammatory activity of leaf essential oil from Cinnamomum longepaniculatum (Gamble) N. Chao.

Authors:  Yong-Hua Du; Rui-Zhang Feng; Qun Li; Qin Wei; Zhong-Qiong Yin; Li-Jun Zhou; Cui Tao; Ren-Yong Jia
Journal:  Int J Clin Exp Med       Date:  2014-12-15

2.  [Inhibition of ultraviolet irradiation response of human skin by topical phlogostatic compounds (author's transl)].

Authors:  E G Weirich; U C Lutz
Journal:  Arch Dermatol Res       Date:  1977-07-21       Impact factor: 3.017

3.  Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition.

Authors:  Li Lu; Aiping Qin; Hongbiao Huang; Ping Zhou; Chuanyin Zhang; Ningning Liu; Shujue Li; Guanmei Wen; Change Zhang; Weihua Dong; Xuejun Wang; Q Ping Dou; Jinbao Liu
Journal:  Eur J Pharmacol       Date:  2011-03-24       Impact factor: 4.432
  3 in total

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