Literature DB >> 9073076

Cloning of the cDNA coding for rat brain CMP-NeuAc:GD3 alpha2-8 sialyltransferase.

G Zeng1, L Gao, R K Yu.   

Abstract

The cDNA coding for GT3-synthase has been cloned from a rat fetal brain cDNA library. The complete nucleotide sequence and the deduced amino acid sequence of the rat GT3-synthase cDNA were highly homologous to those of the mouse GT3-synthase. Quantitative RT-PCR showed that, as a key enzyme for the synthesis of 'c'-series gangliosides, the expression of GT3-synthase was developmentally regulated in embryonic rat brains.

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Year:  1997        PMID: 9073076     DOI: 10.1016/s0378-1119(96)00735-4

Source DB:  PubMed          Journal:  Gene        ISSN: 0378-1119            Impact factor:   3.688


  1 in total

Review 1.  Cloning and transcriptional regulation of genes responsible for synthesis of gangliosides.

Authors:  Guichao Zeng; Robert K Yu
Journal:  Curr Drug Targets       Date:  2008-04       Impact factor: 3.465

  1 in total

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