Early outcome in acute ischemic stroke is not influenced by the prophylactic use of low-dose aspirin.

Aspirin reduces the occurrence of ischemic strokes. In some prophylactic trials it was suggested that aspirin might also lessen stroke severity, and hence improve outcome in patients sustaining an ischemic stroke. We examined stroke severity (by using the Mathew scale) and early outcome (Barthel index and mortality on day 21) in 91 patients with an acute (< 24 h) ischemic stroke in the territory of the middle cerebral artery. Twenty-seven patients were taking low-dose aspirin (100 or 200 mg/day) prior to their stroke, and 64 were not using antiplatelet drugs. There were no significant differences in baseline stroke severity, early (21 days) mortality or early disability between the two groups. The results of this small study suggest that the use of low-dose aspirin prior to an ischemic stroke does not influence the severity of that stroke and early outcome.