| Literature DB >> 9071906 |
E Bouffet1, C Mottolese, A Jouvet, I Philip, D Frappaz, C Carrie, M Brunat-Mentigny.
Abstract
The addition of conventional chemotherapy to irradiation has improved the outcome of children with malignant gliomas. The application of high-dose chemotherapy has been proposed as a possible way to increase the response rate and thus the survival in children with malignant brain tumours. High-dose etoposide (500 mg/m2/day x 3) and thiotepa (300 mg/m2/day x 3) followed by bone marrow transplantation were given to 22 patients (age range 4-20 years) with newly diagnosed or recurrent high-grade glioma. The response rate in the 14 assessable patients was 29% with one complete and three partial responses. 5 patients had stable disease, and 5 progressive disease. 2 patients died of treatment-related toxicity. Only 3 patients remain alive disease free 54, 60 and 65 months after high-dose therapy. For children with high-grade gliomas, survival using high-dose chemotherapy is no better than that reported with conventional treatments.Entities:
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Year: 1997 PMID： 9071906 DOI： 10.1016/s0959-8049(96)00369-3
Source DB: PubMed Journal: Eur J Cancer ISSN： 0959-8049 Impact factor: 9.162