PURPOSE: Two cases of hepatitis B virus (HBV) infection after penetrating keratoplasty are presented. METHODS: An extensive clinical and serologic investigation of these two transplant recipients was performed. In addition, the medical histories, autopsy reports, and specimens of blood from the two deceased corneal tissue donors were retrieved and studied. RESULTS: Serum from both donors was positive for hepatitis B surface antigen; the clinical history and serologic testing of both recipients strongly suggest that the HBV infection in each case was acquired from donor corneal tissue. CONCLUSION: To our knowledge, these are the first documented cases of HBV infection after corneal transplantation. Eye banks should continue to screen donors for HBV.
PURPOSE: Two cases of hepatitis B virus (HBV) infection after penetrating keratoplasty are presented. METHODS: An extensive clinical and serologic investigation of these two transplant recipients was performed. In addition, the medical histories, autopsy reports, and specimens of blood from the two deceased corneal tissue donors were retrieved and studied. RESULTS: Serum from both donors was positive for hepatitis B surface antigen; the clinical history and serologic testing of both recipients strongly suggest that the HBV infection in each case was acquired from donor corneal tissue. CONCLUSION: To our knowledge, these are the first documented cases of HBV infection after corneal transplantation. Eye banks should continue to screen donors for HBV.
Authors: Bradley J Blitvich; Tian Wang; Vandana Saxena; Shemin Zeng; Karen M Harmon; Matthew D Raymond; Kenneth M Goins; Cynthia R Reed; Robert F Mullins; Mark A Greiner Journal: Am J Trop Med Hyg Date: 2016-09-26 Impact factor: 2.345
Authors: Dianna M Blau; Ingrid B Rabe; Julu Bhatnagar; Rachel Civen; Kavita K Trivedi; Dominique Rollin; Susan N Hocevar; Matthew Kuehnert; J Erin Staples; Sherif R Zaki; Marc Fischer Journal: Emerg Infect Dis Date: 2013 Impact factor: 6.883