Literature DB >> 9070915

Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family.

M Veugelers1, J Vermeesch, G Reekmans, R Steinfeld, P Marynen, G David.   

Abstract

The four vertebrate glypican-related integral membrane proteoglycans identified so far constitute a discrete family of heparan sulfate proteoglycans that are linked to the cell surface via glycosyl phosphatidylinositol. In addition to the GPI anchor and substitution with heparan sulfate, the members of this family show significant sequence homology and share a unique and characteristic cysteine motif. Starting from an EST entry that showed significant sequence similarity to MXR7 and OCI-5 (coding, respectively, for human and rat glypican-3), we have isolated a human cDNA coding for glypican-5, a novel member of this proteoglycan family. The gene for this novel glypican (GPC5) maps to 13q32. In the adult, it is primarily expressed in brain tissue.

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Year:  1997        PMID： 9070915     DOI： 10.1006/geno.1996.4518

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  31 in total

Review 1.  Glypicans: proteoglycans with a surprise.

Authors:  J Filmus; S B Selleck
Journal:  J Clin Invest       Date:  2001-08       Impact factor: 14.808

2.  Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud.

Authors:  A Karihaloo; S A Karumanchi; J Barasch; V Jha; C H Nickel; J Yang; S Grisaru; K T Bush; S Nigam; N D Rosenblum; V P Sukhatme; L G Cantley
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-16       Impact factor: 11.205

3.  GPC5 gene and its related pathways in lung cancer.

Authors:  Yafei Li; Ping Yang
Journal:  J Thorac Oncol       Date:  2011-01       Impact factor: 15.609

Review 4.  The contribution of in vivo manipulation of gene expression to the understanding of the function of glypicans.

Authors:  Jorge Filmus
Journal:  Glycoconj J       Date:  2002 May-Jun       Impact factor: 2.916

5.  Cloning and expression of MXR7 gene in human HCC tissue.

Authors:  Xue-Ping Zhou; Hong-Yang Wang; Guang-Shun Yang; Zheng-Jun Chen; Bao-An Li; Meng-Chao Wu
Journal:  World J Gastroenterol       Date:  2000-02       Impact factor: 5.742

6.  Common variation in GPC5 is associated with acquired nephrotic syndrome.

Authors:  Koji Okamoto; Katsushi Tokunaga; Kent Doi; Toshiro Fujita; Hodaka Suzuki; Tetsuo Katoh; Tsuyoshi Watanabe; Nao Nishida; Akihiko Mabuchi; Atsushi Takahashi; Michiaki Kubo; Shiro Maeda; Yusuke Nakamura; Eisei Noiri
Journal:  Nat Genet       Date:  2011-03-27       Impact factor: 38.330

Review 7.  Role of Matricellular Proteins in Disorders of the Central Nervous System.

Authors:  A R Jayakumar; A Apeksha; M D Norenberg
Journal:  Neurochem Res       Date:  2016-11-23       Impact factor: 3.996

Review 8.  Single nucleotide polymorphisms in multiple sclerosis: disease susceptibility and treatment response biomarkers.

Authors:  Vera Pravica; Dusan Popadic; Emina Savic; Milos Markovic; Jelena Drulovic; Marija Mostarica-Stojkovic
Journal:  Immunol Res       Date:  2012-04       Impact factor: 2.829

9.  GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines.

Authors:  Wei Yu; Jun Inoue; Issei Imoto; Yoshinobu Matsuo; Abraham Karpas; Johji Inazawa
Journal:  J Hum Genet       Date:  2003-04-29       Impact factor: 3.172

10.  Multiple sclerosis susceptibility alleles in African Americans.

Authors:  B A Johnson; J Wang; E M Taylor; S J Caillier; J Herbert; O A Khan; A H Cross; P L De Jager; P-A F Gourraud; B C A Cree; S L Hauser; J R Oksenberg
Journal:  Genes Immun       Date:  2009-10-29       Impact factor: 2.676
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