| Literature DB >> 9070285 |
O I Aruoma1, M Whiteman, T G England, B Halliwell.
Abstract
The superoxide radical (O.2-) and nitric oxide (NO.) combine very rapidly to form peroxynitrite (ONOO-), a reactive tissue damaging nitrogen species thought to be involved in the pathology of several chronic diseases. The natural product ergothioneine protects against the nitration of tyrosine and the inactivation of alpha 1-antiproteinase by ONOO-. Ergothioneine merits further investigation as a biological and therapeutic antioxidant agent.Entities:
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Year: 1997 PMID: 9070285 DOI: 10.1006/bbrc.1997.6109
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN: 0006-291X Impact factor: 3.575