Further comments on novel schedule TLVs.

The general formula approach for the development of TLVs for novel work schedules represents a reasonable first attempt in dealing with this new industrial health problem. However, several additional factors should be considered in the derivation of novel work schedule TLVs. They include: 1. the individuals who are at increased risk with respect to the pollutant in question; 2. the possible influences of rotational changes and disrupted circadian rhythms on health status of workers adopting the proposed novel schedules; 3. the type of toxicologic response to be affected and the degree of safety margin built into the TLV; 4. the metabolic rate and fate of the substance in the individual.