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Literature DB >> 9069260

The complexity of Raf-1 regulation.

Abstract

The activation of the serine/threonine kinase Raf-1 is proving to be an intricate multistep process. Recent advances in elucidating how Raf-1 becomes activated in response to signaling events have emphasized the role of phosphorylation and protein interactions in Raf-1 regulation. The picture clearly emerging is that Raf-1 activity can be regulated by multiple mechanisms.

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Year: 1997 PMID： 9069260 DOI： 10.1016/s0955-0674(97)80060-9

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

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Cited

143 in total

1. A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction.

Authors: D S Sieburth; M Sundaram; R M Howard; M Han
Journal: Genes Dev Date: 1999-10-01 Impact factor: 11.361

2. S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3.

Authors: A Chiloeches; C S Mason; R Marais
Journal: Mol Cell Biol Date: 2001-04 Impact factor: 4.272

3. Functional characterization of the interaction of Ste50p with Ste11p MAPKKK in Saccharomyces cerevisiae.

Authors: C Wu; E Leberer; D Y Thomas; M Whiteway
Journal: Mol Biol Cell Date: 1999-07 Impact factor: 4.138

4. The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases.

Authors: T Okada; C D Hu; T G Jin; K Kariya; Y Yamawaki-Kataoka; T Kataoka
Journal: Mol Cell Biol Date: 1999-09 Impact factor: 4.272

10. A lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of Ras pathway genes in Caenorhabditis elegans.

Authors: Christian E Rocheleau; Robyn M Howard; Alissa P Goldman; Mandy L Volk; Laura J Girard; Meera V Sundaram
Journal: Genetics Date: 2002-05 Impact factor: 4.562

The complexity of Raf-1 regulation.

1. A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction.

2. S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3.

3. Functional characterization of the interaction of Ste50p with Ste11p MAPKKK in Saccharomyces cerevisiae.

4. The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases.

5. Isoform-specific localization of A-RAF in mitochondria.

6. Phospholipase C(epsilon): a novel Ras effector.

7. Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.

Review 8. Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions.

9. 14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity.

10. A lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of Ras pathway genes in Caenorhabditis elegans.