BACKGROUND: The spontaneous diurnal variation of mood and other symptoms provides a substrate for the examination of the relationship between symptoms and regional brain activation in depression. METHOD: Twenty unipolar depressed patients with diurnal variation of mood were examined at 8 a.m. and 8 p.m. with neuropsychological measures, clinical ratings and single photon emission tomography (SPET). Brain perfusion maps were spatially transformed into standard stereotactic space and compared pixel-by-pixel. A parametric (correlational) analysis was used to examine the relationship between symptom severity and brain perfusion, both between and within subjects. RESULTS: Global depression severity and an independent 'vital' depression factor were associated in subjects with increased perfusion in cingulate and other paralimbic areas. In addition there was a probable association between an increase in an anxious-depression factor and reduced frontal neocortical perfusion. CONCLUSIONS: Depressive symptom changes are associated with metabolic changes in the cingulate gyrus and associated paralimbic structures.
BACKGROUND: The spontaneous diurnal variation of mood and other symptoms provides a substrate for the examination of the relationship between symptoms and regional brain activation in depression. METHOD: Twenty unipolar depressedpatients with diurnal variation of mood were examined at 8 a.m. and 8 p.m. with neuropsychological measures, clinical ratings and single photon emission tomography (SPET). Brain perfusion maps were spatially transformed into standard stereotactic space and compared pixel-by-pixel. A parametric (correlational) analysis was used to examine the relationship between symptom severity and brain perfusion, both between and within subjects. RESULTS:Global depression severity and an independent 'vital' depression factor were associated in subjects with increased perfusion in cingulate and other paralimbic areas. In addition there was a probable association between an increase in an anxious-depression factor and reduced frontal neocortical perfusion. CONCLUSIONS: Depressive symptom changes are associated with metabolic changes in the cingulate gyrus and associated paralimbic structures.
Authors: Xiaomeng Xu; Beth A Jerskey; Denise M Cote; Edward G Walsh; Jason J Hassenstab; Maura E Ladino; Uraina S Clark; Donald R Labbe; John J Gunstad; Athena Poppas; Ronald A Cohen; Richard D Hoge; Lawrence H Sweet Journal: Neurosci Lett Date: 2013-12-17 Impact factor: 3.046
Authors: Ishita Parikh; Janet Guo; Kai-Hsiang Chuang; Yu Zhong; Ralf G Rempe; Jared D Hoffman; Rachel Armstrong; Björn Bauer; Anika M S Hartz; Ai-Ling Lin Journal: Aging (Albany NY) Date: 2016-11-08 Impact factor: 5.682
Authors: David Ma; Amy C Wang; Ishita Parikh; Stefan J Green; Jared D Hoffman; George Chlipala; M Paul Murphy; Brent S Sokola; Björn Bauer; Anika M S Hartz; Ai-Ling Lin Journal: Sci Rep Date: 2018-04-27 Impact factor: 4.379
Authors: Jared D Hoffman; Ishita Parikh; Stefan J Green; George Chlipala; Robert P Mohney; Mignon Keaton; Bjoern Bauer; Anika M S Hartz; Ai-Ling Lin Journal: Front Aging Neurosci Date: 2017-09-25 Impact factor: 5.750