Literature DB >> 9066269

The JAK-STAT pathway in Drosophila.

X S Hou1, N Perrimon.   

Abstract

Recent studies in Drosophila have identified a single JAK and a single STAT protein. Genetic and biochemical analyses reveal that these two proteins operate in the same signal transduction pathway. Phenotypic analyses of JAK and STAT mutants implicate this pathway in a number of developmental decisions, in particular the regulation of pair-rule genes and fly hematopoiesis.

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Year:  1997        PMID： 9066269     DOI： 10.1016/s0168-9525(97)01006-8

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  11 in total

1.  Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling.

Authors:  Byung Hak Kim; Yun Sook Min; Jung Sook Choi; Gyeong Hun Baeg; Young Soo Kim; Jong Wook Shin; Tae Yoon Kim; Sang Kyu Ye
Journal:  Exp Mol Med       Date:  2011-05-31       Impact factor: 8.718

Review 2.  Severe combined immune deficiencies due to defects of the common gamma chain-JAK3 signaling pathway.

Authors:  F Candotti; J J O'Shea; A Villa
Journal:  Springer Semin Immunopathol       Date:  1998

Review 3.  Advances in the understanding of cytokine signal transduction: the role of Jaks and STATs in immunoregulation and the pathogenesis of immunodeficiency.

Authors:  J J O'Shea; L D Notarangelo; J A Johnston; F Candotti
Journal:  J Clin Immunol       Date:  1997-11       Impact factor: 8.317

4.  mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family.

Authors:  Hua-Wei Chen; Xiu Chen; Su-Wan Oh; Maria J Marinissen; J Silvio Gutkind; Steven X Hou
Journal:  Genes Dev       Date:  2002-02-01       Impact factor: 11.361

5.  The nucleus- and endoplasmic reticulum-targeted forms of protein tyrosine phosphatase 61F regulate Drosophila growth, life span, and fecundity.

Authors:  Bree J Buszard; Travis K Johnson; Tzu-Ching Meng; Richard Burke; Coral G Warr; Tony Tiganis
Journal:  Mol Cell Biol       Date:  2013-01-22       Impact factor: 4.272

6.  Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway.

Authors:  D A Harrison; P E McCoon; R Binari; M Gilman; N Perrimon
Journal:  Genes Dev       Date:  1998-10-15       Impact factor: 11.361

7.  A comprehensive analysis of the Manduca sexta immunotranscriptome.

Authors:  Ramesh T Gunaratna; Haobo Jiang
Journal:  Dev Comp Immunol       Date:  2012-11-23       Impact factor: 3.636

8.  Gene expression in a Drosophila model of mitochondrial disease.

Authors:  Daniel J M Fernández-Ayala; Shanjun Chen; Esko Kemppainen; Kevin M C O'Dell; Howard T Jacobs
Journal:  PLoS One       Date:  2010-01-06       Impact factor: 3.240

9.  STAT3 is required for the gp130-mediated full activation of the c-myc gene.

Authors:  N Kiuchi; K Nakajima; M Ichiba; T Fukada; M Narimatsu; K Mizuno; M Hibi; T Hirano
Journal:  J Exp Med       Date:  1999-01-04       Impact factor: 14.307

10.  Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila.

Authors:  Willis X Li; Herve Agaisse; Bernard Mathey-Prevot; Norbert Perrimon
Journal:  Development       Date:  2002-09       Impact factor: 6.868
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