Studies on the synthesis and biological activity of 3-(substituted anilinomethyl)-4-(5-substituted-2-furfurylidene)amino-1,2,4 -triazole-5- thiones and their Mannich bases.

A series of 3-(substituted anilinomethyl)-4-(5-substituted-2- furfurylidene)amino-1,2,4-triazole-5-thiones were synthesized as potential biologically active agents. They were converted to Mannich bases, by treating with suitable amine in the presence of formaldehyde in alcohol medium. The newly synthesized compounds were screened for their antibacterial and antifungal activities.