Literature DB >> 9065615

Dose-dependent protective effect of BPC 157 on capsaicin-induced rhinitis in rats.

L Kalogjera1, M Ries, T Baudoin, Z Ferencic, R Trotic, B Pegan.   

Abstract

Protection of BPC 157 on capsaicin-induced rhinitis was studied in Wistar rats for its effect on mastocyte infiltration, degranulation and inflammatory cell infiltration. Animals were pretreated with 10 microg/kg, 10 ng/kg or 2 ml saline i.p. and capsaicin (0.05 ml/nostril of 1750 nmol/l sol.) was applied intranasally. They were then euthanized at 1, 3 and 12 h after capsaicin provocation. Nasal mucosa was analyzed and scored for mastocyte infiltration, degranulation and inflammatory cell infiltration. BPC 157 pretreatment significantly prevented mastocyte infiltration at 1 h. Polymorphonuclear leukocyte infiltration was significantly reduced in rats pretreated with 10 microg/kg BPC 157. A dose-dependent effect of BPC 157 pretreatment was demonstrated only for polymorphonuclear leukocyte infiltration at 12 h.

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Year:  1997        PMID： 9065615     DOI： 10.1007/bf02439711

Source DB:  PubMed          Journal:  Eur Arch Otorhinolaryngol        ISSN： 0937-4477            Impact factor:   2.503


  7 in total

1.  Substance P induces granulocyte infiltration through degranulation of mast cells.

Authors:  H Matsuda; K Kawakita; Y Kiso; T Nakano; Y Kitamura
Journal:  J Immunol       Date:  1989-02-01       Impact factor: 5.422

Review 2.  Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides.

Authors:  P Holzer
Journal:  Neuroscience       Date:  1988-03       Impact factor: 3.590

Review 3.  A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC.

Authors:  P Sikirić; M Petek; R Rucman; S Seiwerth; Z Grabarević; I Rotkvić; B Turković; V Jagić; B Mildner; M Duvnjak
Journal:  J Physiol Paris       Date:  1993

4.  Effect of topical glucocorticoid treatment on nasal mucosal mast cells in allergic rhinitis.

Authors:  U Pipkorn
Journal:  Allergy       Date:  1983-02       Impact factor: 13.146

5.  Beneficial effect of a novel pentadecapeptide BPC 157 on gastric lesions induced by restraint stress, ethanol, indomethacin, and capsaicin neurotoxicity.

Authors:  P Sikirić; S Seiwerth; Z Grabarević; R Rucman; M Petek; V Jagić; B Turković; I Rotkvić; S Mise; I Zoricić; M Gjurasin; P Konjevoda; J Separović; D Ljubanović; B Artuković; M Bratulić; M Tisljar; L Jurina; G Buljat; P Miklić; A Marović
Journal:  Dig Dis Sci       Date:  1996-08       Impact factor: 3.199

6.  BPC-15 reduces trinitrobenzene sulfonic acid-induced colonic damage in rats.

Authors:  M Veljaca; C A Lesch; R Pllana; B Sanchez; K Chan; A Guglietta
Journal:  J Pharmacol Exp Ther       Date:  1995-01       Impact factor: 4.030

7.  Capsaicin evokes secretion of nasal fluid and depletes substance P and calcitonin gene-related peptide from the nasal mucosa in the rat.

Authors:  G Petersson; L Malm; R Ekman; R Håkanson
Journal:  Br J Pharmacol       Date:  1989-11       Impact factor: 8.739
  7 in total
  5 in total

1.  The pharmacological properties of the novel peptide BPC 157 (PL-10).

Authors:  P Sikiric
Journal:  Inflammopharmacology       Date:  1999       Impact factor: 4.473

2.  Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL14736, Pliva, Croatia) heals ileoileal anastomosis in the rat.

Authors:  Tihomir Vuksic; Ivan Zoricic; Luka Brcic; Marko Sever; Robert Klicek; Bozo Radic; Vedran Cesarec; Lidija Berkopic; Neike Keller; Alenka Boban Blagaic; Neven Kokic; Ivan Jelic; Juraj Geber; Tomislav Anic; Sven Seiwerth; Predrag Sikiric
Journal:  Surg Today       Date:  2007-08-27       Impact factor: 2.549

3.  Therapy for unhealed gastrocutaneous fistulas in rats as a model for analogous healing of persistent skin wounds and persistent gastric ulcers: stable gastric pentadecapeptide BPC 157, atropine, ranitidine, and omeprazole.

Authors:  Sandra Skorjanec; Zdravko Dolovski; Ivan Kocman; Luka Brcic; Alenka Blagaic Boban; Lovorka Batelja; Marjana Coric; Marko Sever; Robert Klicek; Lidija Berkopic; Bozo Radic; Domagoj Drmic; Danijela Kolenc; Spomenko Ilic; Vedran Cesarec; Ante Tonkic; Ivan Zoricic; Stjepan Mise; Mario Staresinic; Mihovil Ivica; Martina Lovric Bencic; Tomislav Anic; Sven Seiwerth; Predrag Sikiric
Journal:  Dig Dis Sci       Date:  2008-07-23       Impact factor: 3.199

4.  Pentadecapeptide BPC 157 Reduces Bleeding and Thrombocytopenia after Amputation in Rats Treated with Heparin, Warfarin, L-NAME and L-Arginine.

Authors:  Mirjana Stupnisek; Antonio Kokot; Domagoj Drmic; Masa Hrelec Patrlj; Anita Zenko Sever; Danijela Kolenc; Bozo Radic; Jelena Suran; Davor Bojic; Aleksandar Vcev; Sven Seiwerth; Predrag Sikiric
Journal:  PLoS One       Date:  2015-04-21       Impact factor: 3.240

Review 5.  Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications.

Authors:  Predrag Sikiric; Sven Seiwerth; Rudolf Rucman; Danijela Kolenc; Lovorka Batelja Vuletic; Domagoj Drmic; Tihomir Grgic; Sanja Strbe; Goran Zukanovic; Dalibor Crvenkovic; Goran Madzarac; Iva Rukavina; Mario Sucic; Marko Baric; Neven Starcevic; Zoran Krstonijevic; Martina Lovric Bencic; Igor Filipcic; Dinko Stancic Rokotov; Josipa Vlainic
Journal:  Curr Neuropharmacol       Date:  2016       Impact factor: 7.363
  5 in total

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