OBJECTIVE: The aim of this study was to screen for disorders and to histologically classify endometrial biopsy specimens from 2964 perimenopausal and postmenopausal women who were candidates for hormonal replacement therapy. STUDY DESIGN: Endometrial biopsy specimens were obtained with a Vabra aspiration curette, processed by standard methods, and stained by hematoxylin and eosin and special methods to reveal subtle features of the endometrium. RESULTS: Of the endometrial biopsy specimens, 68.7% were atrophic, 23.5% were proliferative, 0.5% were secretory, 0.6% were hyperplastic, 0.07% were adenocarcinoma, and 6.6% were insufficient for classification. Three independent senior microscopists agreed on the classification of each biopsy specimen. CONCLUSION: The number of patients is the largest ever screened for a single hormone replacement therapy study. The low yield of endometrial cancer indicates that biopsies are unnecessary before hormone replacement therapy is initiated in asymptomatic women.
RCT Entities:
OBJECTIVE: The aim of this study was to screen for disorders and to histologically classify endometrial biopsy specimens from 2964 perimenopausal and postmenopausal women who were candidates for hormonal replacement therapy. STUDY DESIGN: Endometrial biopsy specimens were obtained with a Vabra aspiration curette, processed by standard methods, and stained by hematoxylin and eosin and special methods to reveal subtle features of the endometrium. RESULTS: Of the endometrial biopsy specimens, 68.7% were atrophic, 23.5% were proliferative, 0.5% were secretory, 0.6% were hyperplastic, 0.07% were adenocarcinoma, and 6.6% were insufficient for classification. Three independent senior microscopists agreed on the classification of each biopsy specimen. CONCLUSION: The number of patients is the largest ever screened for a single hormone replacement therapy study. The low yield of endometrial cancer indicates that biopsies are unnecessary before hormone replacement therapy is initiated in asymptomatic women.
Authors: Susan D Reed; Katherine M Newton; Walter L Clinton; Meira Epplein; Rochelle Garcia; Kimberly Allison; Lynda F Voigt; Noel S Weiss Journal: Am J Obstet Gynecol Date: 2009-04-23 Impact factor: 8.661
Authors: Meira Epplein; Susan D Reed; Lynda F Voigt; Katherine M Newton; Victoria L Holt; Noel S Weiss Journal: Am J Epidemiol Date: 2008-08-05 Impact factor: 4.897
Authors: Meira Epplein; Susan D Reed; Lynda F Voigt; Katherine M Newton; Victoria L Holt; Noel S Weiss Journal: Ann Epidemiol Date: 2009-01 Impact factor: 3.797
Authors: Tae Hoon Kim; Jung-Yoon Yoo; Zhong Wang; John P Lydon; Shikha Khatri; Shannon M Hawkins; Richard E Leach; Asgerally T Fazleabas; Steven L Young; Bruce A Lessey; Bon Jeong Ku; Jae-Wook Jeong Journal: PLoS Genet Date: 2015-09-17 Impact factor: 5.917
Authors: Juliana Nicoletti Pessoa; Ana Carolina Lopes Freitas; Ronney Antonio Guimaraes; Jonnymar Lima; Helena Lucia Barroso Dos Reis; Antonio Chambo Filho Journal: J Clin Med Res Date: 2013-12-13