| Literature DB >> 9063854 |
A Kawai1, S Sugihara, T Kunisada, M Hamada, H Inoue.
Abstract
The relationship between dose intensity of cytotoxic agents and therapeutic results was examined in a retrospective analysis of 32 patients with non-metastatic high-grade osteosarcoma of the extremities. The average dose intensities of individual agents were 9.8 mg/m2/week for doxorubicin, 1.2 g/m2/week for methotrexate, and 10.5 mg/m2/week for cisplatinum. The dose intensities of doxorubicin and methotrexate were significantly correlated with the clinical results, while that of cisplatinum was not. These results indicate that maximal dose intensification of doxorubicin and methotrexate is an important determinant of treatment outcome for patients with osteosarcoma.Entities:
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Year: 1996 PMID： 9063854 DOI： 10.1007/bf00573443
Source DB: PubMed Journal: Arch Orthop Trauma Surg ISSN： 0936-8051 Impact factor: 3.067