Literature DB >> 9063100

Cytotoxicity and electron microscopy of cell death induced by goniothalamin.

A M Ali1, M M Mackeen, M Hamid, Q B Aun, Y Zauyah, H L Azimahtol, K Kawazu.   

Abstract

The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultrastructural level, goniothalamin-induced cytotoxicity revealed a necrotic mode of cell death towards MCF-7 cells.

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Year:  1997        PMID： 9063100     DOI： 10.1055/s-2006-957611

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  8 in total

1.  Goniothalamin-induced oxidative stress, DNA damage and apoptosis via caspase-2 independent and Bcl-2 independent pathways in Jurkat T-cells.

Authors:  S H Inayat-Hussain; K M Chan; N F Rajab; L B Din; S C Chow; A Kizilors; F Farzaneh; G T Williams
Journal:  Toxicol Lett       Date:  2009-12-22       Impact factor: 4.372

2.  Goniothalamus species: a source of drugs for the treatment of cancers and bacterial infections?

Authors:  Christophe Wiart
Journal:  Evid Based Complement Alternat Med       Date:  2007-09       Impact factor: 2.629

3.  Altholactone displays promising antimicrobial activity.

Authors:  Fouad Al Momani; Ahmad S Alkofahi; Nizar M Mhaidat
Journal:  Molecules       Date:  2011-06-03       Impact factor: 4.411

4.  Goniothalamin Induces Necroptosis and Anoikis in Human Invasive Breast Cancer MDA-MB-231 Cells.

Authors:  Patompong Khaw-On; Wilart Pompimon; Ratana Banjerdpongchai
Journal:  Int J Mol Sci       Date:  2019-08-14       Impact factor: 5.923

5.  RACK-1 overexpression protects against goniothalamin-induced cell death.

Authors:  S H Inayat-Hussain; L T Wong; K M Chan; N F Rajab; L B Din; R Harun; A Kizilors; N Saxena; M Mourtada-Maarabouni; F Farzaneh; G T Williams
Journal:  Toxicol Lett       Date:  2009-08-19       Impact factor: 4.372

6.  Cytotoxicity, Antiproliferative Effects, and Apoptosis Induction of Methanolic Extract of Cynometra cauliflora Linn. Whole Fruit on Human Promyelocytic Leukemia HL-60 Cells.

Authors:  T-Johari S A Tajudin; Nashriyah Mat; Abu Bakar Siti-Aishah; A Aziz M Yusran; Afnani Alwi; Abdul Manaf Ali
Journal:  Evid Based Complement Alternat Med       Date:  2012-11-04       Impact factor: 2.629

Review 7.  Emerging anticancer potentials of goniothalamin and its molecular mechanisms.

Authors:  Mohamed Ali Seyed; Ibrahim Jantan; Syed Nasir Abbas Bukhari
Journal:  Biomed Res Int       Date:  2014-08-28       Impact factor: 3.411

8.  Involvement of Seladin-1 in goniothalamin-induced apoptosis in urinary bladder cancer cells.

Authors:  Heng Kai Yen; Afifah-Radiah Fauzi; Laily Bin Din; Valerie J McKelvey-Martin; Chan Kok Meng; Salmaan Hussain Inayat-Hussain; Nor Fadilah Rajab
Journal:  BMC Complement Altern Med       Date:  2014-08-09       Impact factor: 3.659
  8 in total

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