Literature DB >> 9061165

Allogeneic vascularized grafting of a human knee joint with postoperative immunosuppression.

G O Hofmann1, M H Kirschner, F D Wagner, W Land, V Bühren.   

Abstract

In this paper we report the first successful allogeneic vascularized transplantation of a fresh and perfused human knee joint. A 17-year-old male had lost his knee in a motorvehicle accident. The graft was harvested from a multiorgan donor, perfused with 41 UW solution and transplanted within 21 h. Osteosyntheses were performed employing intramedullary nails. Immunosuppression was based mainly on two drugs: cyclosporin A and azathioprine. Five months after the operation the patient is fully mobilized, and the graft perfusion still intact. Osteotomies of the femur and tibia demonstrate callus formation and osseous consolidation.

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Year:  1997        PMID: 9061165     DOI: 10.1007/bf00426059

Source DB:  PubMed          Journal:  Arch Orthop Trauma Surg        ISSN: 0936-8051            Impact factor:   3.067


  7 in total

1.  Past, present, and future prospects for inducing donor-specific transplantation tolerance for composite tissue allotransplantation.

Authors:  Larry D Bozulic; Warren C Breidenbach; Suzanne T Ildstad
Journal:  Semin Plast Surg       Date:  2007-11       Impact factor: 2.314

Review 2.  Composite tissue transplantation: a rapidly advancing field.

Authors:  K V Ravindra; S Wu; L Bozulic; H Xu; W C Breidenbach; S T Ildstad
Journal:  Transplant Proc       Date:  2008-06       Impact factor: 1.066

Review 3.  [Healing of free vascularized bone allotransplants: optimizing by short-term immunosuppression and host-derived neovascularization].

Authors:  G A Giessler; P F Friedrich; R H Shin; A T Bishop
Journal:  Unfallchirurg       Date:  2009-05       Impact factor: 1.000

Review 4.  Composite tissue allotransplantation and reconstructive surgery: first clinical applications.

Authors:  François Petit; Alicia B Minns; Jean-Michel Dubernard; Shehan Hettiaratchy; W P Andrew Lee
Journal:  Ann Surg       Date:  2003-01       Impact factor: 12.969

Review 5.  Science of composite tissue allotransplantation.

Authors:  Bruce Swearingen; Kadiyala Ravindra; Hong Xu; Shengli Wu; Warren C Breidenbach; Suzanne T Ildstad
Journal:  Transplantation       Date:  2008-09-15       Impact factor: 4.939

6.  Transplant chimerism in porcine structural vascularized bone allotransplants.

Authors:  Rudolph H Houben; Ross A Aleff; Patricia F Friedrich; Alexander Y Shin; Eric D Wieben; Andre J van Wijnen; Allen T Bishop
Journal:  Gene       Date:  2020-03-26       Impact factor: 3.688

7.  Transplantation of composite tissue allograft: scientific bases and clinical applications.

Authors:  C Giuglea; C Coman; S Marinescu; I Florescu; I Lascar
Journal:  J Med Life       Date:  2013-03-25
  7 in total

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