Literature DB >> 9061025

Characterization of human cyclooxygenase 2 gene promoter localization of a TGF-beta response element.

X Yang1, F Hou, L Taylor, P Polgar.   

Abstract

We characterized 2.3 kb of 5'-flanking region of the human cyclooxygenase 2 gene and analyzed its promoter activity. We localized three positive and two negative cis-acting regulatory regions and a TGF-beta response region. Basal promoter activity was located between -77 and +99 bp. Maximal promoter activity was observed from -1838 to +99 bp. A TGF-beta response region was found between -454 and -288 bp. This region included an NF-I site. Electrophoretic mobility shift assays showed that TGF-beta caused a marked change in the pattern and intensity of this NF-I like protein complex.

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Year:  1997        PMID： 9061025     DOI： 10.1016/s0167-4781(96)00225-4

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  10 in total

1.  The regulation of prostaglandin output from term intact fetal membranes by anti-inflammatory cytokines.

Authors:  N L Brown; S A Alvi; M G Elder; P R Bennett; M H Sullivan
Journal:  Immunology       Date:  2000-01       Impact factor: 7.397

Review 2.  Mechanoregulation of gene expression in fibroblasts.

Authors:  James H-C Wang; Bhavani P Thampatty; Jeen-Shang Lin; Hee-Jeong Im
Journal:  Gene       Date:  2007-01-31       Impact factor: 3.688

3.  Involvement of reactive oxygen species in cyclic stretch-induced NF-kappaB activation in human fibroblast cells.

Authors:  Hideki Amma; Keiji Naruse; Naoki Ishiguro; Masahiro Sokabe
Journal:  Br J Pharmacol       Date:  2005-06       Impact factor: 8.739

4.  Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice.

Authors:  C B Keerthisingam; R G Jenkins; N K Harrison; N A Hernandez-Rodriguez; H Booth; G J Laurent; S L Hart; M L Foster; R J McAnulty
Journal:  Am J Pathol       Date:  2001-04       Impact factor: 4.307

5.  The production of interleukin-1beta from human fetal membranes is not obligatory for increased prostaglandin output.

Authors:  S A Alvi; D Rajasingam; N L Brown; M G Elder; P R Bennett; M H Sullivan
Journal:  Immunology       Date:  1999-06       Impact factor: 7.397

6.  Effects of transforming growth factor-beta in the development of inflammatory pseudotumour-like lesions in a murine model.

Authors:  Luciana Doria Guariniello; Mariangela Correa; Miriam Galvonas Jasiulionis; Joel Machado; José Antônio Silva; João Bosco Pesquero; Célia Regina Whitaker Carneiro
Journal:  Int J Exp Pathol       Date:  2006-06       Impact factor: 1.925

7.  TGF-beta1 reduces the heterogeneity of astrocytic cyclooxygenase-2 and nitric oxide synthase-2 gene expression in a stimulus-independent manner.

Authors:  Mary E Hamby; James A Hewett; Sandra J Hewett
Journal:  Prostaglandins Other Lipid Mediat       Date:  2007-12-08       Impact factor: 3.072

8.  NFI-Ski interactions mediate transforming growth factor beta modulation of human papillomavirus type 16 early gene expression.

Authors:  Amy Baldwin; Lucia Pirisi; Kim E Creek
Journal:  J Virol       Date:  2004-04       Impact factor: 5.103

9.  TGF-β Signaling Plays a Pivotal Role During Developmental Biliary Atresia in Sea Lamprey (Petromyzon marinus).

Authors:  Yu-Wen Chung-Davidson; Jianfeng Ren; Chu-Yin Yeh; Ugo Bussy; Belinda Huerta; Peter Joseph Davidson; Steven Whyard; Weiming Li
Journal:  Hepatol Commun       Date:  2019-12-24

10.  Interaction between cyclooxygenase-2 gene polymorphism and dietary n-6 polyunsaturated fatty acids on colon cancer risk: the Singapore Chinese Health Study.

Authors:  W-P Koh; J-M Yuan; D van den Berg; H-P Lee; M C Yu
Journal:  Br J Cancer       Date:  2004-05-04       Impact factor: 7.640
  10 in total

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