Literature DB >> 9061014

Requirement of cofactors for RXR/RAR-mediated transcriptional activation in vitro.

R Valcárcel1, M Meyer, M Meisterernst, H G Stunnenberg.   

Abstract

Using crude in vitro systems, we have previously shown that RXR/RAR heterodimers are able to activate transcription from the RAR beta 2 promoter in a retinoid-dependent manner. Here we demonstrate that cofactors distinct from general transcription factors or receptors are required to mediate retinoic acid-dependent transcription in vitro.

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Year:  1997        PMID: 9061014     DOI: 10.1016/s0167-4781(96)00234-5

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  3 in total

1.  Phosphorylation of histone H3 is functionally linked to retinoic acid receptor beta promoter activation.

Authors:  Bruno Lefebvre; Keiko Ozato; Philippe Lefebvre
Journal:  EMBO Rep       Date:  2002-03-15       Impact factor: 8.807

2.  Chromosomal integration of retinoic acid response elements prevents cooperative transcriptional activation by retinoic acid receptor and retinoid X receptor.

Authors:  Bruno Lefebvre; Céline Brand; Philippe Lefebvre; Keiko Ozato
Journal:  Mol Cell Biol       Date:  2002-03       Impact factor: 4.272

3.  A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system.

Authors:  C Rachez; Z Suldan; J Ward; C P Chang; D Burakov; H Erdjument-Bromage; P Tempst; L P Freedman
Journal:  Genes Dev       Date:  1998-06-15       Impact factor: 11.361

  3 in total

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