| Literature DB >> 9058537 |
A Fang1, D L Pierson, S K Mishra, D W Koenig, A L Demain.
Abstract
In a continuing study of microbial secondary metabolism in simulated microgravity, we have examined gramicidin S (GS) production by Bacillus brevis strain Nagano in NASA High Aspect Rotating Vessels (HARVs), which are designed to simulate some aspects of microgravity. Growth and GS production were found to occur under simulated microgravity. When performance under simulated microgravity was compared with that under normal gravity conditions in the bioreactors, GS production was found to be unaffected by simulated microgravity. The repressive effect of glycerol in flask fermentations was not observed in the HARV. Thus the negative effect of glycerol on specific GS formation is dependent on shear and/or vessel geometry, not gravity.Entities:
Keywords: NASA Center JSC; NASA Discipline Environmental Health; NASA Discipline Number 04-10; NASA Program Environmental Health
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Year: 1997 PMID： 9058537 DOI： 10.1007/s002849900168
Source DB: PubMed Journal: Curr Microbiol ISSN： 0343-8651 Impact factor: 2.188