Literature DB >> 9058289

Regenerating gene expression in normal gastric mucosa and indomethacin-induced mucosal lesions of the rat.

C Kawanami1, H Fukui, Y Kinoshita, H Nakata, M Asahara, Y Matsushima, K Kishi, T Chiba.   

Abstract

Regenerating (reg) gene expression was tested in rat gastrointestinal mucosa to investigate the role played by this gene in the healing of mucosal lesions. Expression of reg mRNA was higher in the stomach than in any other region of the gastrointestinal tract. The gastric cells that expressed reg mRNA were located in the deepest mucosal layer and were small in diameter. In an injured state following indomethacin treatment, reg gene expression was markedly augmented, accompanied by an increase of c-fos expression and healing of the mucosal lesions. These results suggest a role of the reg gene in the healing of gastrointestinal mucosal lesions.

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Year:  1997        PMID： 9058289     DOI： 10.1007/bf01213290

Source DB:  PubMed          Journal:  J Gastroenterol        ISSN： 0944-1174            Impact factor:   7.527


  24 in total

1.  Isolation and characterization of human reg protein produced in Saccharomyces cerevisiae.

Authors:  T Itoh; H Tsuzuki; T Katoh; H Teraoka; K Matsumoto; N Yoshida; K Terazono; T Watanabe; H Yonekura; H Yamamoto
Journal:  FEBS Lett       Date:  1990-10-15       Impact factor: 4.124

2.  A novel gene activated in regenerating islets.

Authors:  K Terazono; H Yamamoto; S Takasawa; K Shiga; Y Yonemura; Y Tochino; H Okamoto
Journal:  J Biol Chem       Date:  1988-02-15       Impact factor: 5.157

3.  On cell proliferation and differentiation of the fundic mucosa of the golden hamster. Fractographic study combined with microscopy and 3H-thymidine autoradiography.

Authors:  T Hattori
Journal:  Cell Tissue Res       Date:  1974-04-11       Impact factor: 5.249

4.  Tritiated thymidine autoradiographic study of cell migration and renewal in the pyloric mucosa of golden hamsters.

Authors:  T Hattori; S Fujita
Journal:  Cell Tissue Res       Date:  1976-11-24       Impact factor: 5.249

5.  Mitogenic response of canine fundic epithelial cells in short-term culture to transforming growth factor alpha and insulinlike growth factor I.

Authors:  M C Chen; A T Lee; A H Soll
Journal:  J Clin Invest       Date:  1991-05       Impact factor: 14.808

6.  Expression of protooncogenes c-fos and c-myc in healing of gastric mucosal stress ulcers.

Authors:  J Y Wang; L R Johnson
Journal:  Am J Physiol       Date:  1994-05

7.  The actions of secretagogues on oxygen uptake by isolated mammalian parietal cells.

Authors:  A H Soll
Journal:  J Clin Invest       Date:  1978-02       Impact factor: 14.808

8.  Gastrin receptor genes are expressed in gastric parietal and enterochromaffin-like cells of Mastomys natalensis.

Authors:  M Asahara; Y Kinoshita; H Nakata; Y Matsushima; Y Naribayashi; A Nakamura; T Matsui; K Chihara; J Yamamoto; A Ichikawa
Journal:  Dig Dis Sci       Date:  1994-10       Impact factor: 3.199

9.  Tritiated thymidine autoradiographic study on cellular migration in the gastric gland of the golden hamster.

Authors:  T Hattori; S Fujita
Journal:  Cell Tissue Res       Date:  1976-09-14       Impact factor: 5.249

10.  Calcitonin gene-related peptide: a neurotransmitter involved in capsaicin-sensitive afferent nerve-mediated gastric mucosal protection.

Authors:  Y Kinoshita; T Inui; T Chiba
Journal:  J Clin Gastroenterol       Date:  1993       Impact factor: 3.062
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  9 in total

1.  REG1B as a predictor of childhood stunting in Bangladesh and Peru.

Authors:  Kristine M Peterson; Janice Buss; Rebecca Easley; Zhengyu Yang; Poonum S Korpe; Feiyang Niu; Jennie Z Ma; Maribel Paredes Olortegui; Rashidul Haque; Margaret N Kosek; William A Petri
Journal:  Am J Clin Nutr       Date:  2013-04-03       Impact factor: 7.045

2.  The expression of REG 1A and REG 1B is increased during acute amebic colitis.

Authors:  Kristine M Peterson; Xiaoti Guo; Abdel G Elkahloun; Dinesh Mondal; Pradip K Bardhan; Akira Sugawara; Priya Duggal; Rashidul Haque; William A Petri
Journal:  Parasitol Int       Date:  2011-05-06       Impact factor: 2.230

3.  Possible role of REG Ialpha protein in ulcerative colitis and colitic cancer.

Authors:  A Sekikawa; H Fukui; S Fujii; A Nanakin; N Kanda; Y Uenoyama; T Sawabu; H Hisatsune; T Kusaka; S Ueno; H Nakase; H Seno; T Fujimori; T Chiba
Journal:  Gut       Date:  2005-05-24       Impact factor: 23.059

Review 4.  Reg gene family and human diseases.

Authors:  Yu-Wei Zhang; Liu-Song Ding; Mao-De Lai
Journal:  World J Gastroenterol       Date:  2003-12       Impact factor: 5.742

Review 5.  Environmental Enteric Dysfunction in Children.

Authors:  Sana Syed; Asad Ali; Christopher Duggan
Journal:  J Pediatr Gastroenterol Nutr       Date:  2016-07       Impact factor: 2.839

Review 6.  Gastric cancer: animal studies on the risk of hypoacidity and hypergastrinemia.

Authors:  Reidar Fossmark; Gunnar Qvigstad; Helge-L Waldum
Journal:  World J Gastroenterol       Date:  2008-03-21       Impact factor: 5.742

7.  Involvement of REG Ialpha protein in the regeneration of ductal epithelial cells in the minor salivary glands of patients with Sjögren's syndrome.

Authors:  T Kimura; H Fukui; A Sekikawa; H Yamagishi; K Ichikawa; S Tomita; S Fujii; J Imura; H Kawamata; T Chiba; Y Imai; T Fujimori
Journal:  Clin Exp Immunol       Date:  2008-11-06       Impact factor: 4.330

8.  Promising Biomarkers of Environmental Enteric Dysfunction: A Prospective Cohort study in Pakistani Children.

Authors:  Najeeha Talat Iqbal; Kamran Sadiq; Sana Syed; Tauseefullah Akhund; Fayyaz Umrani; Sheraz Ahmed; Mohammad Yawar Yakoob; Najeeb Rahman; Shahida Qureshi; Wenjun Xin; Jennie Z Ma; Molly Hughes; Syed Asad Ali
Journal:  Sci Rep       Date:  2018-02-14       Impact factor: 4.379

9.  Assessment of Environmental Enteric Dysfunction in the SHINE Trial: Methods and Challenges.

Authors:  Andrew J Prendergast; Jean H Humphrey; Kuda Mutasa; Florence D Majo; Sandra Rukobo; Margaret Govha; Mduduzi N N Mbuya; Lawrence H Moulton; Rebecca J Stoltzfus
Journal:  Clin Infect Dis       Date:  2015-12-15       Impact factor: 9.079
  9 in total

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