Literature DB >> 9056383

Thyroid hormone regulates NGF content and p75LNGFR expression in the basal forebrain of adult rats.

L Calzà1, L Giardino, L Aloe.   

Abstract

Several lines of data from human and animal studies have suggested a role of thyroid hormone in the regulation of cholinergic neurons in the adult brain. In this study we have investigated the content of nerve growth factor (NGF) and the expression of NGF low affinity receptor (p75(LNGFR)) in the basal forebrain of adult hypothyroid rats. We describe an increase of both NGF and p75(LNGFR) expression in the basal forebrain of adult hypothyroid rats. The administration of colchicine up-regulates p75(LNGFR) expression in both hypo- and control rats, whereas it fails to down-regulate choline acetyl transferase mRNA expression during hypothyroidism. These data offer a possible neurobiological explanation to cognitive defects observed during adult hypothyroidism in humans.

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Year:  1997        PMID： 9056383     DOI： 10.1006/exnr.1996.6361

Source DB:  PubMed          Journal:  Exp Neurol        ISSN： 0014-4886            Impact factor:   5.330


  7 in total

1.  Silencing of Wnt signaling and activation of multiple metabolic pathways in response to thyroid hormone-stimulated cell proliferation.

Authors:  L D Miller; K S Park; Q M Guo; N W Alkharouf; R L Malek; N H Lee; E T Liu; S Y Cheng
Journal:  Mol Cell Biol       Date:  2001-10       Impact factor: 4.272

Review 2.  Action of thyroid hormone in brain.

Authors:  J Bernal
Journal:  J Endocrinol Invest       Date:  2002-03       Impact factor: 4.256

3.  Thyroid hormone activates oligodendrocyte precursors and increases a myelin-forming protein and NGF content in the spinal cord during experimental allergic encephalomyelitis.

Authors:  Laura Calza; Mercedes Fernandez; Alessandro Giuliani; Luigi Aloe; Luciana Giardino
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-26       Impact factor: 11.205

4.  Hormonal influences on brain ageing quality: focus on corticotropin releasing hormone-, vasopressin- and oxytocin-immunoreactive neurones in the human brain.

Authors:  L Calzà; M Pozza; F Coraddu; G Farci; L Giardino
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

5.  Thyroid function and the risk of Alzheimer disease: the Framingham Study.

Authors:  Zaldy S Tan; Alexa Beiser; Ramachandran S Vasan; Rhoda Au; Sanford Auerbach; Douglas P Kiel; Philip A Wolf; Sudha Seshadri
Journal:  Arch Intern Med       Date:  2008-07-28

6.  Study on NGF and VEGF during the Equine Perinatal Period-Part 2: Foals Affected by Neonatal Encephalopathy.

Authors:  Nicola Ellero; Aliai Lanci; Vito Antonio Baldassarro; Giuseppe Alastra; Jole Mariella; Maura Cescatti; Carolina Castagnetti; Luciana Giardino
Journal:  Vet Sci       Date:  2022-08-26

7.  The Association Between Thyroid Diseases and Alzheimer's Disease in a National Health Screening Cohort in Korea.

Authors:  Ji Hee Kim; Heui Seung Lee; Yoo Hwan Kim; Mi Jung Kwon; Joo-Hee Kim; Chan Yang Min; Dae Myoung Yoo; Hyo Geun Choi
Journal:  Front Endocrinol (Lausanne)       Date:  2022-03-07       Impact factor: 5.555
  7 in total

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