Literature DB >> 9053550

Practical guide for morphometry of human peroxisomes on electron micrographs.

I Kerckaert1, D De Craemer, G Van Limbergen.   

Abstract

Morphometry of peroxisomes is performed on electron micrographs of ultrathin sections after staining for catalase activity with diaminobenzidine; specific peroxisomal labelling is preferred to guarantee recognition. Peroxisomal number, size, axial ratio and volume parameters are determined and compared to control values. Results from 19 patients with loss of peroxisomal functions are listed. In many patients alterations in peroxisomal morphometric features are found. A brief guideline for interpreting morphometric data is included. Diagnostically relevant morphometric alterations are summarized.

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Year:  1995        PMID： 9053550     DOI： 10.1007/bf00711438

Source DB:  PubMed          Journal:  J Inherit Metab Dis        ISSN： 0141-8955            Impact factor:   4.982


  31 in total

1.  Bone dysplasia associated with phytanic acid accumulation and deficient plasmalogen synthesis: a peroxisomal entity amenable to plasmapheresis.

Authors:  J A Smeitink; F A Beemer; M Espeel; R A Donckerwolcke; C Jakobs; R J Wanders; R B Schutgens; F Roels; M Duran; L Dorland
Journal:  J Inherit Metab Dis       Date:  1992       Impact factor: 4.982

2.  Pathology of hepatic peroxisomes and mitochondria in patients with peroxisomal disorders.

Authors:  J L Hughes; A Poulos; E Robertson; C W Chow; L J Sheffield; J Christodoulou; R F Carter
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1990

Review 3.  Human liver pathology in peroxisomal diseases: a review including novel data.

Authors:  F Roels; M Espeel; F Poggi; H Mandel; L van Maldergem; J M Saudubray
Journal:  Biochimie       Date:  1993       Impact factor: 4.079

4.  Cytoplasmic catalase and ghostlike peroxisomes in the liver from a child with atypical chondrodysplasia punctata.

Authors:  M Espeel; J C Heikoop; J A Smeitink; F A Beemer; D De Craemer; M Van den Berg; T Hashimoto; R J Wanders; R B Schutgens; B T Poll-The
Journal:  Ultrastruct Pathol       Date:  1993 Nov-Dec       Impact factor: 1.094

5.  Hepatic peroxisomes in adrenoleukodystrophy and related syndromes: cytochemical and morphometric data.

Authors:  F Roels; M Pauwels; B T Poll-Thé; J Scotto; H Ogier; P Aubourg; J M Saudubray
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1988

6.  Neonatal seizures and severe hypotonia in a male infant suffering from a defect in peroxisomal beta-oxidation.

Authors:  L Van Maldergem; M Espeel; R J Wanders; F Roels; P Gerard; E Scalais; G P Mannaerts; M Casteels; Y Gillerot
Journal:  Neuromuscul Disord       Date:  1992       Impact factor: 4.296

7.  Peroxisomal defects in neonatal-onset and X-linked adrenoleukodystrophies.

Authors:  S Goldfischer; J Collins; I Rapin; B Coltoff-Schiller; C H Chang; M Nigro; V H Black; N B Javitt; H W Moser; P B Lazarow
Journal:  Science       Date:  1985-01-04       Impact factor: 47.728

8.  Hepatic peroxisomes are deficient in infantile refsum disease: a cytochemical study of 4 cases.

Authors:  F Roels; A Cornelis; B T Poll-The; P Aubourg; H Ogier; J Scotto; J M Saudubray
Journal:  Am J Med Genet       Date:  1986-10

9.  Practical stereological methods for morphometric cytology.

Authors:  E R Weibel; G S Kistler; W F Scherle
Journal:  J Cell Biol       Date:  1966-07       Impact factor: 10.539

10.  A quantitative stereological description of the ultrastructure of normal rat liver parenchymal cells.

Authors:  A V Loud
Journal:  J Cell Biol       Date:  1968-04       Impact factor: 10.539
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  2 in total

1.  Immunocytochemical localization of peroxisomal proteins in human liver and kidney.

Authors:  M Espeel; G Van Limbergen
Journal:  J Inherit Metab Dis       Date:  1995       Impact factor: 4.982

2.  Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator.

Authors:  Catherine Gondcaille; Marianne Depreter; Stéphane Fourcade; Maria Rita Lecca; Sabrina Leclercq; Pascal G P Martin; Thierry Pineau; Françoise Cadepond; Martine ElEtr; Nathalie Bertrand; Alain Beley; Sandrine Duclos; Dirk De Craemer; Frank Roels; Stéphane Savary; Maurice Bugaut
Journal:  J Cell Biol       Date:  2005-04-04       Impact factor: 10.539
  2 in total

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