Comparison of cocaine-induced vasoconstriction of left and right coronary arterial systems.

In patients undergoing cardiac catheterization, we measured left and right coronary arterial dimensions before and 15 minutes after intranasal saline (n = 8) or cocaine (n = 8). In response to cocaine, left and right coronary arterial areas declined by 11 +/- 6% and 12 +/- 11%, respectively; thus, intranasal cocaine induces a similar magnitude of vasoconstriction of the left and right coronary arteries.