Literature DB >> 9051908

Argenteanones C-E and argenteanols B-E, cytotoxic cycloartanes from Aglaia argentea.

K Mohamad1, M T Martin, E Leroy, C Tempête, T Sévenet, K Awang, M Païs.   

Abstract

Seven new cycloartanes, argenteanones C-E (4-6) and argenteanols B-E (7-10), have been isolated from Aglaia argentea leaves. All of these compounds possess significant cytotoxic activity against KB cells (IC50 values between 3.7 and 6.2 micrograms/mL). Structure elucidation was performed by 2D NMR spectroscopy, aided by molecular modeling in the case of the side chain of compound 7.

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Year:  1997        PMID: 9051908     DOI: 10.1021/np960594c

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  3 in total

Review 1.  Chemistry and biology of rocaglamides (= flavaglines) and related derivatives from aglaia species (meliaceae).

Authors:  Sherif S Ebada; Neil Lajkiewicz; John A Porco; Min Li-Weber; Peter Proksch
Journal:  Prog Chem Org Nat Prod       Date:  2011

2.  Bioactive flavaglines and other constituents isolated from Aglaia perviridis.

Authors:  Li Pan; Ulyana Muñoz Acuña; Jie Li; Nivedita Jena; Tran Ngoc Ninh; Caroline M Pannell; Heebyung Chai; James R Fuchs; Esperanza J Carcache de Blanco; Djaja D Soejarto; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2013-01-09       Impact factor: 4.050

3.  Triterpenoids from Aglaia abbreviata exert cytotoxicity and multidrug resistant reversal effect in MCF-7/ADM cells via reactive oxygen species induction and P-glycoprotein inhibition.

Authors:  Juan Cen; Beibei Zheng; Rubing Bai; Li Zhang; Feng Zhang; Xia Zhang
Journal:  Oncotarget       Date:  2017-04-20
  3 in total

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