Literature DB >> 9051762

The Mel1a melatonin receptor gene is expressed in human suprachiasmatic nuclei.

D R Weaver1, S M Reppert.   

Abstract

The pineal hormone melatonin influences circadian rhythmicity in many vertebrate species. The circadian effects of melatonin in humans have led to its use to treat jet lag and circadian-based sleep disorders. Melatonin is thought to influence circadian rhythmicity by acting in the suprachiasmatic nuclei (SCN). The recent cloning of two melatonin receptor subtypes with high affinity for melatonin allows molecular analysis of melatonin receptors in human SCN. We report that Mel1a receptor mRNA is detectable in neonatal human SCN by in situ hybridization. Mel1b and melatonin-related receptor mRNAs were not detected. The presence of Mel1a receptor mRNA in human SCN supports the hypothesis that the Mel1a receptor is responsible for the circadian effects of melatonin in humans.

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Year:  1996        PMID： 9051762     DOI： 10.1097/00001756-199612200-00022

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  21 in total

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Review 5.  Melatonin in Alzheimer's Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer's Neuropathology.

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Journal:  Mol Neurobiol       Date:  2019-06-17       Impact factor: 5.590

6.  Distribution of MT1 melatonin receptor promoter-driven RFP expression in the brains of BAC C3H/HeN transgenic mice.

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Review 9.  Role of the melatonin system in the control of sleep: therapeutic implications.

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Review 10.  Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?

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Journal:  Br J Pharmacol       Date:  2008-05-19       Impact factor: 8.739
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