| Literature DB >> 9050 |
G de Groot, R A Maes, H H Lemmens.
Abstract
A method is described for the determination of lorazepam plasma levels involving extraction from the sample and analysis of the intact lorazepam by electron capture gas-liquid chromatography. Using mass spectrometry it is demonstrated, that lorazepam shows a thermal rearrangement under gas chromatographic conditions. The limit of detection is 0.01 mg/l and the assay shows a linearity from 0.01-0.80 mg lorazepam per liter of plasma.Entities:
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Year: 1976 PMID： 9050 DOI： 10.1007/BF00293571
Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153