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Literature DB >> 9049827

Patterns of oncogene activation in human neuroblastoma cells.

Abstract

Human neuroblastoma is the most frequent solid tumor in children. Recent studies suggest that a multiplicity of genomic alterations contributes to neuroblastoma, the most frequent and well studied being deletion of the short arm of chromosome 1 and amplification of N-MYC. We here present and discuss different patterns of oncogene activation including, amplification of N-MYC, duplication of N-MYC and amplification of MDM2.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1997 PMID： 9049827 DOI： 10.1023/a:1005721027709

Source DB: PubMed Journal: J Neurooncol ISSN： 0167-594X Impact factor: 4.130

35 in total

1. Cytogenetic evolution of MYCN and MDM2 amplification in the neuroblastoma LS tumour and its cell line.

Authors: R Corvi; L Savelyeva; L Amler; R Handgretinger; M Schwab
Journal: Eur J Cancer Date: 1995 Impact factor: 9.162

2. Amplification of a gene encoding a p53-associated protein in human sarcomas.

Authors: J D Oliner; K W Kinzler; P S Meltzer; D L George; B Vogelstein
Journal: Nature Date: 1992-07-02 Impact factor: 49.962

3. Amplified N-myc in human neuroblastoma cells is often arranged as clustered tandem repeats of differently recombined DNA.

Authors: L C Amler; M Schwab
Journal: Mol Cell Biol Date: 1989-11 Impact factor: 4.272

4. Translocation involving 1p and 17q is a recurrent genetic alteration of human neuroblastoma cells.

Authors: L Savelyeva; R Corvi; M Schwab
Journal: Am J Hum Genet Date: 1994-08 Impact factor: 11.025

5. Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors.

Authors: U M Moll; M LaQuaglia; J Bénard; G Riou
Journal: Proc Natl Acad Sci U S A Date: 1995-05-09 Impact factor: 11.205

6. Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc.

Authors: M Schwab; H E Varmus; J M Bishop; K H Grzeschik; S L Naylor; A Y Sakaguchi; G Brodeur; J Trent
Journal: Nature Date: 1984 Mar 15-21 Impact factor: 49.962

7. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage.

Authors: G M Brodeur; R C Seeger; M Schwab; H E Varmus; J M Bishop
Journal: Science Date: 1984-06-08 Impact factor: 47.728

8. p53 Mutation and MDM2 amplification in human soft tissue sarcomas.

Authors: F S Leach; T Tokino; P Meltzer; M Burrell; J D Oliner; S Smith; D E Hill; D Sidransky; K W Kinzler; B Vogelstein
Journal: Cancer Res Date: 1993-05-15 Impact factor: 12.701

9. Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product.

Authors: A K Rustgi; N Dyson; R Bernards
Journal: Nature Date: 1991-08-08 Impact factor: 49.962

10. MDM2 gene amplification in metastatic osteosarcoma.

Authors: M Ladanyi; C Cha; R Lewis; S C Jhanwar; A G Huvos; J H Healey
Journal: Cancer Res Date: 1993-01-01 Impact factor: 12.701

5 in total

1. Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems.

Authors: Swati S More; Melissa Itsara; Xiaodong Yang; Ethan G Geier; Michelle K Tadano; Youngho Seo; Henry F Vanbrocklin; William A Weiss; Sabine Mueller; Daphne A Haas-Kogan; Steven G Dubois; Katherine K Matthay; Kathleen M Giacomini
Journal: Clin Cancer Res Date: 2011-03-18 Impact factor: 12.531