AIM: To investigate fatalities from myocardial infarction at 28 days and one-year among patients aged 35-64 years in the Nordic and Lithuanian centres participating in the World Health Organization MONICA (Monitoring of Trends and Determinants of Cardiovascular Disease) Project. METHODS AND RESULTS: Altogether 9100 myocardial infarction events registered according to the protocol of the MONICA Project were included in the study. For these events, one-year follow-up was carried out using routine mortality statistics. Fatalities were expressed as age-standardized means per year for a 3-year period from the mid-1980s. The myocardial infarction fatalities at 28 days (including out-of-hospital deaths) in the eight participating populations varied among men, between 36.5% (95% confidence interval 32.6-40.4%) in Iceland and 54.6% (51.2-57.9%) in Kaunas, Lithuania, Among women, it varied from 32.4% (26.4-38.4%) in Iceland to 57.5% (51.8-63.2%) in Glostrup, Denmark. More than half of this mortality occurred suddenly and the patient did not reach hospital alive. Fatalities for the period from day 28 to one year varied among men, from 5.3% (2.9-7.6%) in Iceland to 10.9% (8.0-13.8%) in North Karelia, Finland, and among women from 3.5% (0.4-6.5%) in Kuopio, Finland, to 13.5% (7.2-19.7%) in Glostrup, Denmark. CONCLUSIONS: Approximately half of the myocardial infarction patients died within one year after the onset of the attack and half of those who died, died out-of-hospital. While the myocardial infarction fatalities differed considerably between the participating populations, differences of this magnitude are unlikely to be totally explained by differences in the registration procedures. Further comparisons of acute coronary care and secondary prevention measures are warranted.
AIM: To investigate fatalities from myocardial infarction at 28 days and one-year among patients aged 35-64 years in the Nordic and Lithuanian centres participating in the World Health Organization MONICA (Monitoring of Trends and Determinants of Cardiovascular Disease) Project. METHODS AND RESULTS: Altogether 9100 myocardial infarction events registered according to the protocol of the MONICA Project were included in the study. For these events, one-year follow-up was carried out using routine mortality statistics. Fatalities were expressed as age-standardized means per year for a 3-year period from the mid-1980s. The myocardial infarction fatalities at 28 days (including out-of-hospital deaths) in the eight participating populations varied among men, between 36.5% (95% confidence interval 32.6-40.4%) in Iceland and 54.6% (51.2-57.9%) in Kaunas, Lithuania, Among women, it varied from 32.4% (26.4-38.4%) in Iceland to 57.5% (51.8-63.2%) in Glostrup, Denmark. More than half of this mortality occurred suddenly and the patient did not reach hospital alive. Fatalities for the period from day 28 to one year varied among men, from 5.3% (2.9-7.6%) in Iceland to 10.9% (8.0-13.8%) in North Karelia, Finland, and among women from 3.5% (0.4-6.5%) in Kuopio, Finland, to 13.5% (7.2-19.7%) in Glostrup, Denmark. CONCLUSIONS: Approximately half of the myocardial infarctionpatients died within one year after the onset of the attack and half of those who died, died out-of-hospital. While the myocardial infarction fatalities differed considerably between the participating populations, differences of this magnitude are unlikely to be totally explained by differences in the registration procedures. Further comparisons of acute coronary care and secondary prevention measures are warranted.
Authors: Kati Kristiansson; Erkki Ilveskoski; Terho Lehtimäki; Leena Peltonen; Markus Perola; Pekka J Karhunen Journal: Arterioscler Thromb Vasc Biol Date: 2008-02-14 Impact factor: 8.311