Literature DB >> 9048973

Chromosome aberrations induced in human lymphocytes by U-235 fission neutrons. Part III: Evaluation of the effect of the induced alpha and beta activity on the chromosomal aberration yield.

A Fajgelj1, D Horvat, J Skrk.   

Abstract

AIM: Further experiments were performed to explain a difference in chromosomal aberration yield found between samples cultivated immediately after fission neutron irradiation and samples which were cultivated with 96 h delay after irradiation. MATERIAL AND
METHOD: Human peripheral blood samples were irradiated in mixed fission neutron/gamma field (1800 s) and biological effect assessed in the mean of analysis of unstable chromosome aberrations with a time delay in culturing cells of 12, 24, 48, and 96 h. Additional measurements were performed on irradiated and blank blood samples with the aim to detect any increase in alpha and beta activity after fission neutron irradiation. No difference was found. Results were compared to theoretically calculated values of the alpha and beta activity released from natural radioactive isotopes. RESULT AND
CONCLUSION: As a conclusion it is shown that in our experimental conditions the secondary effects resulting from nuclear transformations of natural or induced radioactive isotopes, recoil reactions and accompanying alpha, beta, and gamma radiation are not the reason for the increase observed in chromosomal aberration yield in blood samples cultured with a time delay of at least 24 hours.

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Year:  1997        PMID: 9048973     DOI: 10.1007/bf03038928

Source DB:  PubMed          Journal:  Strahlenther Onkol        ISSN: 0179-7158            Impact factor:   3.621


  7 in total

1.  Chromosome aberrations induced in human lymphocytes by U-235 fission neutrons. Part II: Evaluation of the effect of the induced Na-24 activity on the chromosomal aberration yield.

Authors:  A Fajgelj; D Horvat; B Pucelj
Journal:  Strahlenther Onkol       Date:  1992-07       Impact factor: 3.621

2.  Enhanced neoplastic transformation due to protracted exposures of fission-spectrum neutrons: biophysical model.

Authors:  M M Elkind
Journal:  Int J Radiat Biol       Date:  1991-06       Impact factor: 2.694

3.  Lack of dose rate modification (0.0049 vs. 0.12 Gy/min) of fission-neutron-induced neoplastic transformation in C3H/10T1/2 cells.

Authors:  E K Balcer-Kubiczek; G H Harrison
Journal:  Int J Radiat Biol       Date:  1991-04       Impact factor: 2.694

4.  The inverse dose-rate effect for oncogenic transformation by neutrons and charged particles: a plausible interpretation consistent with published data.

Authors:  D J Brenner; E J Hall
Journal:  Int J Radiat Biol       Date:  1990-11       Impact factor: 2.694

5.  Fission-spectrum neutrons at reduced dose rates enhance neoplastic transformation.

Authors:  C K Hill; F M Buonaguro; C P Myers; A Han; M M Elkind
Journal:  Nature       Date:  1982-07-01       Impact factor: 49.962

6.  Delayed chromosomal instability in human T-lymphocyte clones exposed to ionizing radiation.

Authors:  K Holmberg; A E Meijer; G Auer; B O Lambert
Journal:  Int J Radiat Biol       Date:  1995-09       Impact factor: 2.694

7.  Chromosome aberrations induced in human lymphocytes by U-235 fission neutrons: I. Irradiation of human blood samples in the "dry cell" of the TRIGA Mark II nuclear reactor.

Authors:  A Fajgelj; A Lakoski; D Horvat; I Remec; J Skrk; P Stegnar
Journal:  Strahlenther Onkol       Date:  1991-11       Impact factor: 3.621

  7 in total

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