Literature DB >> 9046353

(+)-7-Deaza-5'-noraristeromycin as an anti-trypanosomal agent.

K L Seley1, S W Schneller, D Rattendi, C J Bacchi.   

Abstract

The (+)-enantiomer of 7-deaza-5'-noraristeromycin (4) has been found to show IC50 values ranging from 0.16 to 5.3 microM against four strains of African trypanosomes, one Trypanosoma brucei brucei isolate, and several clinical isolates of Trypanosoma brucei rhodesiense (agent of east African sleeping sickness), including a multidrug resistant clone of one isolate. While this compound was originally designed to inhibit S-adenosyl-L-homocysteine hydrolase, it has been found to have no effect on this enzyme.

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Year:  1997        PMID： 9046353     DOI： 10.1021/jm9605039

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  6 in total

1.  Synthesis and antitrypanosomal activities of a series of 7-deaza-5'-noraristeromycin derivatives with variations in the cyclopentyl ring substituents.

Authors:  K L Seley; S W Schneller; D Rattendi; S Lane; C J Bacchi
Journal:  Antimicrob Agents Chemother       Date:  1997-08       Impact factor: 5.191

2.  Synthesis of New 5'-Norcarbocyclic Aza/Deaza Purine Fleximers - Noncompetitive Inhibitors of E.coli Purine Nucleoside Phosphorylase.

Authors:  Anastasia Khandazhinskaya; Ilja Fateev; Irina Konstantinova; Roman Esipov; Konstantin Polyakov; Katherine Seley-Radtke; Sergey Kochetkov; Elena Matyugina
Journal:  Front Chem       Date:  2022-05-04       Impact factor: 5.545

3.  Structural insight into binding mode of inhibitor with SAHH of Plasmodium and human: interaction of curcumin with anti-malarial drug targets.

Authors:  Dev Bukhsh Singh; Seema Dwivedi
Journal:  J Chem Biol       Date:  2016-08-15

4.  Design and synthesis of a series of truncated neplanocin fleximers.

Authors:  Sarah C Zimmermann; Elizaveta O'Neill; Godwin U Ebiloma; Lynsey J M Wallace; Harry P De Koning; Katherine L Seley-Radtke
Journal:  Molecules       Date:  2014-12-16       Impact factor: 4.411

Review 5.  The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold.

Authors:  Katherine L Seley-Radtke; Mary K Yates
Journal:  Antiviral Res       Date:  2018-04-10       Impact factor: 10.103

Review 6.  The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold.

Authors:  Mary K Yates; Katherine L Seley-Radtke
Journal:  Antiviral Res       Date:  2018-12-08       Impact factor: 10.103
  6 in total

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