| Literature DB >> 9045953 |
Y Fujimitsu1, H Nakanishi, K Inada, T Yamachika, M Ichinose, H Fukami, M Tatematsu.
Abstract
Morphological analysis of isolated colonic crypts in rats, postnatally, indicated that the crypts reproduce themselves by a fission mechanism, the division beginning at the crypt base and proceeding upwards until there are two separate crypts. Occasionally, before the separation is complete, a second fission process starts on one or both sides of a bifurcating crypt and a triple-branched or quadruple-branched crypt results. Analysis of isolated aberrant crypt foci (ACF) in rats treated with 1,2-dimethylhydrazine revealed that the development of ACF consisting of multiple crypts is also due to a fission mechanism. Initially, an indentation appears at the base of a single ACF crypt, with subsequent formation of a bifurcation and eventual crypt division.Entities:
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Year: 1996 PMID： 9045953 PMCID： PMC5921030 DOI： 10.1111/j.1349-7006.1996.tb03133.x
Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050